2-formylbenzyl allyl chloroformate

Base Information

• Chemical Name: 2-formylbenzyl allyl chloroformate
• CAS No.: 1407162-52-0
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.225
• Mol file: 1407162-52-0.mol

Synonyms:2-formylbenzyl allyl chloroformate

Chemical Property of 2-formylbenzyl allyl chloroformate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-formylbenzyl allyl chloroformate

There total 2 articles about 2-formylbenzyl allyl chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(hydroxymethyl)benzyl allyl chloroformate (1407162-51-9) → 2-formylbenzyl allyl chloroformate (1407162-52-0)

Guidance literature:

With manganese(IV) oxide; In chloroform; at 20 ℃; for 48h;

DOI:10.1021/ja3069648

Reference yield:

phthalyl alcohol (612-14-6) → 2-formylbenzyl allyl chloroformate (1407162-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 0 - 20 °C

2: manganese(IV) oxide / chloroform / 48 h / 20 °C

With manganese(IV) oxide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; chloroform;

DOI:10.1021/ja3069648

Reference yield: 75.0%

(3S,5S)-3-amino-1,5-bis(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (1407162-55-3) + 2-formylbenzyl allyl chloroformate (1407162-52-0) → (3S,5S)-1,5-bis[(tert-butoxy)carbonyl]-3-({[2-({[(prop-2-en-1-yloxy)carbonyl]oxy}methyl)phenyl]methyl}amino)pyrrolidine-3-carboxylic acid (1407162-62-2)

Guidance literature:

(3S,5S)-3-amino-1,5-bis(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid; 2-formylbenzyl allyl chloroformate; In methanol; at 20 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 12h;

DOI:10.1021/ja3069648

upstream raw materials:

phthalyl alcohol

2-(hydroxymethyl)benzyl allyl chloroformate

Downstream raw materials:

(3S,5S)-1,5-bis[(tert-butoxy)carbonyl]-3-({[2-({[(prop-2-en-1-yloxy)carbonyl]oxy}methyl)phenyl]methyl}amino)pyrrolidine-3-carboxylic acid

(3R,5R)-1,5-bis[(tert-butoxy)carbonyl]-3-({[2-({[(prop-2-en-1-yloxy)carbonyl]oxy}methyl)phenyl]methyl}amino)pyrrolidine-3-carboxylic acid

(3R,5S)-1,5-bis[(tert-butoxy)carbonyl]-3-({[2-({[(prop-2-en-1-yloxy)carbonyl]oxy}methyl)phenyl]methyl}amino)pyrrolidine-3-carboxylic acid