Technology Process of 2-(hydroxymethyl)benzyl allyl chloroformate
There total 1 articles about 2-(hydroxymethyl)benzyl allyl chloroformate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran;
at 0 - 20 ℃;
DOI:10.1021/ja3069648
- Guidance literature:
-
With
manganese(IV) oxide;
In
chloroform;
at 20 ℃;
for 48h;
DOI:10.1021/ja3069648
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: manganese(IV) oxide / chloroform / 48 h / 20 °C
2.1: methanol / 0.5 h / 20 °C
2.2: 12 h / 20 °C
3.1: triethylamine / tetrahydrofuran / 24 h / 20 °C
4.1: chlorotriisopropylsilane; trifluoroacetic acid / 4 h / 20 °C
5.1: triethylamine / tetrahydrofuran / 0 - 20 °C
6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere
6.2: 20 °C
7.1: tetrakis(triphenylphosphine) palladium(0); borane dimethylamine complex / N,N-dimethyl-formamide / 24 h / 20 °C
7.2: 3 h / 20 °C
8.1: chloroform-d1 / 22 °C
With
manganese(IV) oxide; tetrakis(triphenylphosphine) palladium(0); chlorotriisopropylsilane; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; borane dimethylamine complex;
In
tetrahydrofuran; methanol; chloroform-d1; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja3069648
