(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

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Chemical Name:(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester
CAS No.:915401-65-9
Molecular Formula:C₂₃H₂₉NO₅
Molecular Weight:399.487
Hs Code.:

Synonyms:(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

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Chemical Property of (S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

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Technology Process of (S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

There total 1 articles about (S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 6272-38-4
O-benzylcatechol

: 67-63-0,8013-70-5
isopropyl alcohol

: 623938-32-9
(2S)-phenylmethyl 2-(oxiran-2-yl)pyrrolidine-1-carboxylate

: (1R,7aS)-1-(2-Benzyloxy-phenoxymethyl)-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

: 915401-65-9
(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

Guidance literature:: With potassium carbonate; for 24h; Heating;
DOI:10.1016/j.bmcl.2006.08.020

Reference yield: 95.0%

: 915401-65-9
(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

: 124-63-0
methanesulfonyl chloride

: 915401-67-1
(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-methanesulfonyloxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

Guidance literature:: With TEA; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.08.020

Reference yield:

: 915401-65-9
(S)-2-[(S)-2-(2-Benzyloxy-phenoxy)-1-hydroxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

: 915401-68-2
(S)-2-[(S)-2-(2-Hydroxy-phenoxy)-1-methanesulfonyloxy-ethyl]-pyrrolidine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / TEA / CH₂Cl₂ / 1 h / 25 °C

2: 79 percent / H₂ / Pd/C / ethanol / 24 h

With TEA; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.08.020