(S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester

Base Information

• Chemical Name: (S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester
• CAS No.: 212568-81-5
• Molecular Formula: C₂₁H₂₈N₈O₂
• Molecular Weight: 424.506

Synonyms:(S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester

Chemical Property of (S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester

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Technology Process of (S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester

There total 2 articles about (S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.8%

H-Phe-OEt (3081-24-1) + 5-Chloro-N2,N2,N7,N7-tetramethyl-pyrimido[4,5-d]pyrimidine-2,4,7-triamine (212568-76-8) → (S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester (212568-81-5)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/S0040-4020(98)00588-2

Reference yield:

4-chloro-5-cyano-2-dimethylamino-6-(dimethylamino-chloro)azomethinopyrimidine → (S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester (212568-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 61.5 percent / aq. NH₄OH / ethanol / 19 h / Heating

2: 49.8 percent / ethanol / Heating

With ammonium hydroxide; In ethanol;

DOI:10.1016/S0040-4020(98)00588-2

Reference yield: 98.8%

(S)-2-(5-Amino-2,7-bis-dimethylamino-pyrimido[4,5-d]pyrimidin-4-ylamino)-3-phenyl-propionic acid ethyl ester (212568-81-5) → (S)-9-Benzyl-2,5-bis-dimethylamino-9,10-dihydro-7H-1,3,4,6,7,10-hexaaza-cyclohepta[de]naphthalen-8-one

Guidance literature:

With sodium ethanolate; In ethanol; for 6h; Heating;

DOI:10.1016/S0040-4020(98)00588-2

upstream raw materials:

H-Phe-OEt

5-Chloro-N²,N²,N⁷,N⁷-tetramethyl-pyrimido[4,5-d]pyrimidine-2,4,7-triamine

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