(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester
CAS No.:111491-71-5
Molecular Formula:C₃₀H₃₄N₂O₃
Molecular Weight:470.612
Hs Code.:

Synonyms:(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

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Chemical Property of (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

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Technology Process of (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

There total 1 articles about (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5893-05-0
Trt-Gly

: 5497-76-7,184719-80-0,256478-96-3
L-proline tert-butyl ester hydrochloride

: 111491-71-5
(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

Guidance literature:: With chloro-trimethyl-silane; triethylamine; carbonochloridic acid, butyl ester; Yield given. Multistep reaction; 1) CH₂Cl₂-DMFA 2) CH₂Cl_2.;
DOI:10.1007/BF00598358

Reference yield:

: 111491-71-5
(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

: 80714-61-0
H-Met-Glu-His-Phe-Pro-Gly-Pro

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / 80percent AcOH / 1 h / 40 °C

2: 1) (CH₃)3SiCl; 2) Et₃N, butyl chloroformate / 1) CH₂Cl₂-DMFA; 2) CH₂Cl_2.

3: 73 percent / hydrogen, Pd black / methanol / 3 h

4: 76 percent / 1) isoamyl nitrite, Et₃N, HCl / dioxane; CHCl₃; dimethylformamide / 1) 0 to 4 deg C, 12 h; 2) 20-25 deg C, 5 h.

5: 88 percent / CF₃COOH, dimethyl sulfide / various solvent(s) / 3 h / 30 °C

With hydrogenchloride; chloro-trimethyl-silane; dimethylsulfide; hydrogen; palladium; acetic acid; triethylamine; carbonochloridic acid, butyl ester; trifluoroacetic acid; isopentyl nitrite; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1007/BF00598358

Reference yield:

: 111491-71-5
(S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester

: 111491-73-7
phenylalanylprolylglycylproline tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / 80percent AcOH / 1 h / 40 °C

2: 1) (CH₃)3SiCl; 2) Et₃N, butyl chloroformate / 1) CH₂Cl₂-DMFA; 2) CH₂Cl_2.

3: 73 percent / hydrogen, Pd black / methanol / 3 h

With chloro-trimethyl-silane; hydrogen; palladium; acetic acid; triethylamine; carbonochloridic acid, butyl ester; In methanol;
DOI:10.1007/BF00598358