5893-05-0

Basic information

• Product Name: TRT-GLY-OH
• Synonyms: TIMTEC-BB SBB002954;TRT-GLYCINE;TRT-GLY-OH;TRITYL-GLYCINE;N-ALPHA-TRITYL-GLYCINE;N-TRITYLGLYCINE;N-(TRIPHENYLMETHYL)GLYCINE;N-Tritylglycine~Trt-Gly-OH
• CAS NO: 5893-05-0
• Molecular Formula: C₂₁H₁₉NO₂
• Molecular Weight: 317.38
• EINECS: 1533716-785-6
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 5893-05-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 172-174°C
• Boiling Point: 480 °C at 760 mmHg
• Flash Point: 244.1 °C
• Appearance: /
• Density: 1.178 g/cm³
• Vapor Pressure: 1.91E-20mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: -15°C
• Solubility: almost transparency in Methanol
• PKA: 2.14±0.10(Predicted)
• BRN: 1998718
• CAS DataBase Reference: TRT-GLY-OH(CAS DataBase Reference)
• NIST Chemistry Reference: TRT-GLY-OH(5893-05-0)
• EPA Substance Registry System: TRT-GLY-OH(5893-05-0)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 5893-05-0(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

N-protected glycine for the preparation of peptides.

InChI:InChI=1/C34H42N4O5/c1-3-4-21-42-27-14-11-25(12-15-27)33(39)36-26-13-16-30(29(23-26)34(40)35-24-28-8-7-22-43-28)37-17-19-38(20-18-37)31-9-5-6-10-32(31)41-2/h5-6,9-16,23,28H,3-4,7-8,17-22,24H2,1-2H3,(H,35,40)(H,36,39)

Upstream product

• 76-83-5 trityl chloride 
• 596-43-0 bromo-triphenyl-methane 
• 10065-71-1 N-tritylglycine methyl ester 
• 5269-37-4 glycine trimethylsilyl ester 
• 7364-42-3 N,O-bis(trimethylsilyl)glycine 
• 3226-97-9 N-tritylglycine trityl ester 
• 18514-46-0 N-(triphenylmethyl)glycine ethyl ester 
• 73488-66-1 N-trityl-glycine benzyl ester 
• 56-40-6 glycine 

Downstream Products

• 51871-26-2 N-trityl-glycine cyanomethyl ester 
• 103046-41-9 N-Triphenylmethyl-glycyl-glykolsaeure-ethylester 
• 73488-67-2 Trt-Gly-Leu-OBzl 
• 111491-71-5 (S)-1-[2-(Trityl-amino)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 92466-09-6 Trt-Gly-Phe-OBzl 
• 131326-19-7 N-tritylglycylglycine 4-chlorobutyl ester 
• 131326-22-2 N-tritylglycyl-L-phenylalanine 4-chlorobutyl ester 
• 134330-59-9 N-[2-(2-Diethylamino-ethyl)-9-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid 
• 134330-61-3 N-[2-(2-Diethylamino-ethyl)-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid 
• 134330-58-8 N-[2-(2-Diethylamino-ethyl)-8-hydroxy-2H-6-thia-1,2-diaza-aceanthrylen-5-yl]-2-(trityl-amino)-acetamide; compound with (trityl-amino)-acetic acid 
• 123872-98-0 N-tritylglycylglycine 2-bromoethyl ester 
• 82774-99-0 Trit-Gly-L-Lys(BOC)-L-Pro-OH 
• 82774-94-5 Trit-Gly-L-Lys(BOC)-OH 
• 4510-06-9 N-Trityl-glycyl-L-leucinmethylester 

Relevant articles and documents

TRITYLATION REACTIONS BASED ON METALLIC CATALYSIS

The invention relates to a method for preparing tritylated compounds in which protic functional groups are protected with the triphenylmethyl group, method based on the homogeneous catalysis exercised by salts or metal complexes in organic solvents. The invention relates in particular to a method for the selective tritylation of some groups, obtained both directly and by selective detritylation, with methods based on metallic catalysis. The application to amino acids, typical substrates not suitable to be subjected as such to homogeneous tritylations in organic solvents, indicates the ability of the method to extend also to hydrophilic substrates. The method allows to obtain with high yield pertrityl amino acids, N-tritylamino acids or amino acids tritylated only in lateral chain, compounds which heretofore were either difficult to obtain in aqueous solvents or obtainable through indirect methods. All, in any case, are important intermediates in peptide synthesis.

Multi-substituted fullerenes and methods for their preparation and characterization

The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo

Preparation of N-Tritylamino Acids from N-Trimethylsilylamino Acid Trimethylsilyl Esters

Persilylated amino acids are used to prepare Nα-tritylamino acids 2,4, and 6 in high yields by cleavage of the Si-N bond with trityl chloride in chloroform under reflux.The side chains of Lys, Orn and Cys are simultaneously tritylated while sil