5893-05-0Relevant articles and documents
TRITYLATION REACTIONS BASED ON METALLIC CATALYSIS
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Page/Page column 30, (2010/11/25)
The invention relates to a method for preparing tritylated compounds in which protic functional groups are protected with the triphenylmethyl group, method based on the homogeneous catalysis exercised by salts or metal complexes in organic solvents. The invention relates in particular to a method for the selective tritylation of some groups, obtained both directly and by selective detritylation, with methods based on metallic catalysis. The application to amino acids, typical substrates not suitable to be subjected as such to homogeneous tritylations in organic solvents, indicates the ability of the method to extend also to hydrophilic substrates. The method allows to obtain with high yield pertrityl amino acids, N-tritylamino acids or amino acids tritylated only in lateral chain, compounds which heretofore were either difficult to obtain in aqueous solvents or obtainable through indirect methods. All, in any case, are important intermediates in peptide synthesis.
Preparations, X-ray crystal structure determinations, and base strength measurements of substituted tritylamines
Canle, Moises L.,Clegg, William,Demirtas, Ibrahim,Elsegood, Mark R.J.,Maskill, Howard
, p. 85 - 92 (2007/10/03)
A range of tritylamines TrNRR′, and 4-methoxy-, 4,4′-dimethoxy-, and 4,4′,4″-trimethoxy-substituted analogues, have been prepared from (substituted) trityl chloride, bromide, or tetrafluoroborate with ammonia or with amines HNRR′ where R and R′ are hydrog
Multi-substituted fullerenes and methods for their preparation and characterization
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, (2008/06/13)
The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of fo
Efficient Synthesis of N-Triphenylmethyl α-Amino Acids
Mutter, Manfred,Hersperger, Rene
, p. 198 - 200 (2007/10/02)
A new one-pot synthesis of N-triphenylmethyl(trityl) α-amino acids 3 via their trityl ester 2 has been developed.
Preparation of N-Tritylamino Acids from N-Trimethylsilylamino Acid Trimethylsilyl Esters
Mamos, Petros,Sanida, Chariklia,Barlos, Kleomenis
, p. 1083 - 1084 (2007/10/02)
Persilylated amino acids are used to prepare Nα-tritylamino acids 2,4, and 6 in high yields by cleavage of the Si-N bond with trityl chloride in chloroform under reflux.The side chains of Lys, Orn and Cys are simultaneously tritylated while sil
Efficient "One-Pot" Synthesis of N-Trityl Amino Acids
Barlos, Kleomenis,Papaioannou, Dionysios,Theodoropoulos, Dimitrios
, p. 1324 - 1326 (2007/10/02)
A sequential procedure has been developed whereby neutral amino acids 1 were tritylated via their corresponding trimethylsilyl esters 2 to afford, after mild hydrolysis, N-trityl amino acids 3 in high yields and purity.Hydroxy amino acids 4 were preferent
