benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

Base Information

Chemical Name:benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate
CAS No.:367924-62-7
Molecular Formula:C₃₉H₅₂N₄O₅
Molecular Weight:656.866
Hs Code.:

benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

Synonyms:benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

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Chemical Property of benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

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Technology Process of benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

There total 9 articles about benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 128422-11-7
N-[(benzyloxy)carbonyl]leucyl-α-aminoisobutyric acid

: 367924-27-4
(S)-2-cyclopentyl-2,N-dimethyl-N-[(R)-1-(naphthalen-1-yl)ethyl]-2H-azirin-3-amine

: 367924-62-7
benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 132h;
DOI:10.1002/1522-2675(20010613)84:6<1756::AID-HLCA1756>3.0.CO;2-J

Reference yield:

: 2018-66-8
Z-Leu-OH

: 367924-62-7
benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / diethyl ether / 2 h / 0 °C

2: 99 percent / HCl / H₂O; tetrahydrofuran / 14 h / 20 °C

3: 39 percent / CH₂Cl₂ / 132 h / 20 °C

With hydrogenchloride; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1002/1522-2675(20010613)84:6<1756::AID-HLCA1756>3.0.CO;2-J

Reference yield:

: 137-43-9
Cyclopentyl bromide

: 367924-62-7
benzyl {(S)-1-{{{-2-{{(S)-1-cyclopentyl-1-methyl-2-{methyl-[(R)-1-(naphthalen-1-yl)ethyl]amino}-2-oxoethyl}amino}-1,1-dimethyl-2-oxoethyl}amino}oxomethyl}-3-methylbutyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA; LiClO₄ / tetrahydrofuran / 0.45 h / 0 °C

1.2: 41 percent / tetrahydrofuran / 23 h / 0 - 20 °C

2.1: 58 percent / Lawesson reagent / toluene / 7 h / 130 °C

3.1: COCl₂ / toluene; CH₂Cl₂; dimethylformamide / 0.42 h / 0 - 20 °C

3.2: DABCO / tetrahydrofuran / 0.33 h / 0 °C

3.3: 0.415 g / NaN₃ / tetrahydrofuran / 8 h / 20 °C

4.1: 39 percent / CH₂Cl₂ / 132 h / 20 °C

With Lawessons reagent; lithium perchlorate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1522-2675(20010613)84:6<1756::AID-HLCA1756>3.0.CO;2-J