(S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

Base Information

Chemical Name:(S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide
CAS No.:1322564-77-1
Molecular Formula:C₁₇H₁₆F₂N₄O₅
Molecular Weight:394.335
Hs Code.:

Synonyms:(S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

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Technology Process of (S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

There total 2 articles about (S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 1322564-49-7
C₉H₈F₃N₃O₃

: 1322564-77-1
(S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 80 ℃; for 1h; under 5171.62 Torr; Microwave irradiation;
DOI:10.1002/cjoc.201190200

Reference yield:

: 16583-08-7
2,3,4,5-tetrafluoro-6-nitrobenzoic acid

: 1322564-77-1
(S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 80 °C / 5171.62 Torr / Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cjoc.201190200

Reference yield:

: 1322564-77-1
(S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide

: C₁₇H₁₈F₂N₄O₃

Guidance literature:: With palladium 10% on activated carbon; ammonium formate; In tetrahydrofuran; ethanol; at 20 ℃;
DOI:10.1002/cjoc.201190200