16583-08-7

Basic information

• Product Name: 2,3,4,5-Tetrafluoro-6-nitrobenzoic acid
• Synonyms: 2,3,4,5-Tetrafluoro-6-nitrobenzoicacid;2-Nitro-3,4,5,6-tetrafluorobenzoic acid
• CAS NO: 16583-08-7
• Molecular Formula: C₇HF₄NO₄
• Molecular Weight: 238.0734
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 16583-08-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 85-87℃
• Boiling Point: 342.585 °C at 760 mmHg
• Flash Point: 160.99 °C
• Appearance: light yellow crystalline powder
• Density: 1.83 g/cm³
• Vapor Pressure: 2.86E-05mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.69±0.39(Predicted)
• CAS DataBase Reference: 2,3,4,5-Tetrafluoro-6-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-Tetrafluoro-6-nitrobenzoic acid(16583-08-7)
• EPA Substance Registry System: 2,3,4,5-Tetrafluoro-6-nitrobenzoic acid(16583-08-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 16583-08-7(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

InChI:InChI=1/C7HF4NO4/c8-2-1(7(13)14)6(12(15)16)5(11)4(10)3(2)9/h(H,13,14)/p-1

Upstream product

• 5580-81-4 2-Brom-3,4,5,6-tetrafluor-acet-anilid 
• 16582-99-3 2-NH₂-C₆F₄CN 
• 5580-82-5 2-bromo-3,4,5,6-tetrafluoroaniline 
• 16583-05-4 2-Nitrotetrafluorbenzonitril 
• 5580-80-3 2,3,4,5-tetrafluoroaniline 
• 5580-79-0 2,3,4,5-tetrafluoro-1-nitrobenzene 
• 551-62-2 1,2,3,4-tetrafluorobenzene 
• 1201-31-6 2,3,4,5-tetrafluorobenzoic acid 
• 16583-07-6 2-NO₂-C₆F₄C(O)NH₂ 

Downstream Products

• 4920-62-1 2-(dimethylamino)-3,4,5,6-tetrafluorobenzoic acid 
• 1322564-49-7 C₉H₈F₃N₃O₃ 
• 1322564-99-7 (S)-2-(1-(benzo[d][1,3]dioxol-5-ylmethyl)-5,7-difluoro-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazol-6-ylamino)propanamide 
• 1322564-96-4 (S)-2-(1-(1-benzylpiperidin-4-yl)-5,7-difluoro-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazol-6-ylamino)propanamide 
• 1322564-93-1 (S)-2-(1-cyclopentyl-5,7-difluoro-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazol-6-ylamino)propanamide 
• 1322564-92-0 (S)-2-(1-(2-(cyclohex-1-en-1-yl)ethyl)-5,7-difluoro-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazol-6-ylamino)propanamide 
• 1322564-91-9 (S)-2-(1-(4-chlorophenethyl)-5,7-difluoro-2-(3,4,5-trimethoxyphenyl)-1H-benzo[d]imidazol-6-ylamino)propanamide 
• 1322564-84-0 C₂₁H₂₅F₂N₅O₃ 
• 1322564-83-9 (S)-2-(3-(cyclopentylamino)-2,6-difluoro-4-nitrophenylamino)propanamide 
• 1322564-82-8 (S)-2-(3-(2-(cyclohex-1-en-1-yl)ethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide 
• 1322564-79-3 (S)-2-(3-(4-chlorophenethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide 
• 1322564-77-1 (S)-2-(3-(benzo[d][1,3]dioxol-5-ylmethylamino)-2,6-difluoro-4-nitrophenylamino)propanamide 
• 1322564-75-9 (S)-2-(2,6-difluoro-4-nitro-3-(pyridin-2-ylmethylamino)phenylamino)propanamide 
• 103772-10-7 2,3,4,5-tetrafluoro-6-nitro-benzoyl chloride 

Relevant articles and documents

An efficient synthesis of 3,5-dimethoxy-2,4-difluorobenzoic acid

3,5-Dimethoxy-2,4-difluorobenzoic acid, as a key intermediate for preparing an impurity of moxifloxacin, was synthesised from 2,3,4,5-tetrafluorobenzoic acid in moderate yield by nitration, methoxyl substitution, reduction of NO2, diazotisation and reduction. The structures of the intermediates and the target compound were identified and determined with IR, NMR and HRMS (ESI).

7-Substituted 5-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids: Synthesis and Biological Activity of a New Class of Quinolone Antibacterials

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