4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

Base Information

Chemical Name:4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate
CAS No.:1338930-82-7
Molecular Formula:C₃₁H₄₄BrFN₄O₆
Molecular Weight:667.616
Hs Code.:

Synonyms:4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Chemical Property of 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Technology Process of 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

There total 9 articles about 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₄₄BrFN₄O₆

: 75-65-0
tert-butyl alcohol

: 1338930-82-7
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

: C₃₃H₄₈BrFN₄O₆

Guidance literature:: tert-butyl alcohol; With lithium amide; at 80 ℃; for 1h; Inert atmosphere;

C₃₁H₄₄BrFN₄O₆; In toluene; acetonitrile; at 30 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In water; ethyl acetate; Inert atmosphere; Saturated solution;
DOI:10.1016/j.bmc.2011.07.042

Reference yield:

: 1245808-57-4
C₁₆H₂₁NO₄

: 1338930-82-7
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

: C₃₃H₄₈BrFN₄O₆

Guidance literature:: Multi-step reaction with 6 steps

1.1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 100 °C / Inert atmosphere

2.1: potassium tert-butylate / toluene / 1 h / 40 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

4.1: acetonitrile / 1 h / 50 °C / Inert atmosphere

4.2: 10 h / 80 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

6.1: lithium amide / 1 h / 80 °C / Inert atmosphere

6.2: 2 h / 30 °C / Inert atmosphere

6.3: Inert atmosphere; Saturated solution

With lithium amide; diphenyl phosphoryl azide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate; triethylamine; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile; 1.1: Curtius rearrangement;
DOI:10.1016/j.bmc.2011.07.042

Reference yield:

: C₁₆H₂₀N₂O₃

: 1338930-82-7
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{3-[(tert-butoxycarbonyl)amino]-3-ethylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

: C₃₃H₄₈BrFN₄O₆

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / toluene / 1 h / 40 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C

3.1: acetonitrile / 1 h / 50 °C / Inert atmosphere

3.2: 10 h / 80 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

5.1: lithium amide / 1 h / 80 °C / Inert atmosphere

5.2: 2 h / 30 °C / Inert atmosphere

5.3: Inert atmosphere; Saturated solution

With lithium amide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmc.2011.07.042