(S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

Base Information

Chemical Name:(S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide
CAS No.:1365533-55-6
Molecular Formula:C₂₂H₃₂BrNO₃SSi
Molecular Weight:498.556
Hs Code.:

Synonyms:(S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

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Chemical Property of (S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

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Technology Process of (S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

There total 4 articles about (S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₈BrNO₃S

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1365533-55-6
(S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 938069-18-2
2-bromo-L-phenylalanine methyl ester

: 1365533-55-6
(S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 16 h / 0 - 20 °C

2.2: 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.01.037

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1365533-55-6
(S)-N-(1-(2-bromophenyl)-3-((tert-butyldimethylsilyl)oxy)propan-2-yl)-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 16 h / 0 - 20 °C

2.2: 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2012.01.037