methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

Base Information

Chemical Name:methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate
CAS No.:1393448-89-9
Molecular Formula:C₂₉H₃₈F₃NO₃
Molecular Weight:505.621
Hs Code.:

Synonyms:methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

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Chemical Property of methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

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Technology Process of methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

There total 5 articles about methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 937-05-3
cis-4-tert-butyl-1-cyclohexanol

: 1393448-88-8
methyl 1-(2,2,2-trifluoro-1-(6-hydroxynaphthalen-2-yl)ethyl)piperidine-4-carboxylate

: 1393448-89-9
methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 886370-42-9
2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethan-1-one

: 1393448-89-9
methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / dichloromethane / 5 h / 20 °C

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: triethylamine / acetonitrile / 13 h / 20 - 130 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 5 h / 0 °C

4.2: 2 h / 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; boron tribromide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1393448-86-6
2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethyl methanesulfonate

: 1393448-89-9
methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 13 h / 20 - 130 °C / Microwave irradiation

2.1: boron tribromide / dichloromethane / 5 h / 0 °C

2.2: 2 h / 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; boron tribromide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile;