2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE

Base Information

• Chemical Name: 2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE
• CAS No.: 886370-42-9
• Molecular Formula: C13H9F3O2
• Molecular Weight: 254.2
• Mol file: 886370-42-9.mol

Synonyms:6-METHOXY-2-TRIFLUOROACETYLNAPHTHALENE;2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE;2-(6-METHOXYNAPHTHYL) TRIFLUOROMETHYL KETONE

Chemical Property of 2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE

Chemical Property:

• Vapor Pressure: 0.00023mmHg at 25°C
• Melting Point: 64-66 °C
• Boiling Point: 325.5°C at 760 mmHg
• Flash Point: 145.7°C
• PSA: 26.30000
• Density: 1.3g/cm³
• LogP: 3.59340

Purity/Quality:

98%min ^*data from raw suppliers

2-(6-Methoxynaphthyl)trifluoromethylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE

There total 9 articles about 2,2,2-TRIFLUORO-1-(6-METHOXY-NAPHTHALEN-2-YL)-ETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethanol → 2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethan-1-one (886370-42-9)

Guidance literature:

2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1021/jacs.5b07573

Reference yield: 77.0%

2-Bromo-6-methoxynaphthalene (5111-65-9) + N-methoxy-N-methyltrifluoroacetamide (104863-67-4) → 2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethan-1-one (886370-42-9)

Guidance literature:

2-Bromo-6-methoxynaphthalene; With magnesium; ethylene dibromide; In diethyl ether; Inert atmosphere; Reflux;

N-methoxy-N-methyltrifluoroacetamide; In diethyl ether; at 0 - 20 ℃;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1016/j.tet.2009.11.053

Reference yield: 72.0%

ethyl trifluoroacetate, (383-63-1) + 2-Bromo-6-methoxynaphthalene (5111-65-9) → 2,2,2-trifluoro-1-(6-methoxynaphthalen-2-yl)ethan-1-one (886370-42-9)

Guidance literature:

2-Bromo-6-methoxynaphthalene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

ethyl trifluoroacetate,; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201916129

upstream raw materials:

2-Bromo-6-methoxynaphthalene

N-methoxy-N-methyltrifluoroacetamide

6-methoxynaphthalene-2-carbaldehyde

ethyl trifluoroacetate,

Downstream raw materials:

1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylic acid

methyl 1-(1-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-2,2,2-trifluoroethyl)piperidine-4-carboxylate

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