(S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester
CAS No.:191102-97-3
Molecular Formula:C₁₇H₂₀N₂O₃S₂
Molecular Weight:364.489
Hs Code.:

Synonyms:(S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

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Chemical Property of (S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

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Technology Process of (S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

There total 6 articles about (S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16426-64-5
2-bromo-4-nitrobenzoic acid

: 191102-97-3
(S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / thionyl chloride / 3 h / Heating

2: 57 percent / trisodium phosphate; Pd(PPh₃)4 / dimethylformamide / 12 h / 100 °C

3: 100 percent / aq. NaOH / methanol / 2 h / Heating

4: 90 percent / Et₃N; EDCI; HOBT / CH₂Cl₂ / 10 h / 20 °C

5: SnCl₂ hydrate

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium phosphate; tin(ll) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Substitution / 3: Hydrolysis / 4: Acylation / 5: Reduction;
DOI:10.1016/S0968-0896(99)00252-7

Reference yield:

: 100959-22-6
methyl 2-bromo-4-nitrobenzoate

: 191102-97-3
(S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / trisodium phosphate; Pd(PPh₃)4 / dimethylformamide / 12 h / 100 °C

2: 100 percent / aq. NaOH / methanol / 2 h / Heating

3: 90 percent / Et₃N; EDCI; HOBT / CH₂Cl₂ / 10 h / 20 °C

4: SnCl₂ hydrate

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium phosphate; tin(ll) chloride; In methanol; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Hydrolysis / 3: Acylation / 4: Reduction;
DOI:10.1016/S0968-0896(99)00252-7

Reference yield:

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 191102-97-3
(S)-2-(4-Amino-2-thiophen-2-yl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Et₃N; EDCI; HOBT / CH₂Cl₂ / 10 h / 20 °C

2: SnCl₂ hydrate

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; In dichloromethane; 1: Acylation / 2: Reduction;
DOI:10.1016/S0968-0896(99)00252-7