methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

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Chemical Name:methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate
CAS No.:122485-75-0
Molecular Formula:C₂₂H₂₆FNO₄
Molecular Weight:387.451
Hs Code.:

Synonyms:methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

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Chemical Property of methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

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Technology Process of methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

There total 4 articles about methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5153-69-5,706-08-1
4-fluoro-β-nitrostyrene

: 122485-75-0
methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

Guidance literature:: Multi-step reaction with 6 steps

1: 22.0 g / sodium methanolate / methanol / 2.25 h / 0 °C

2: 7.3 g / methanol / 1.) 40 deg C, 2 h, 2.) 50 deg C, 5 h

3: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

4: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium methylate; triethylamine; In methanol; diethyl ether;
DOI:10.1021/jm00163a011

Reference yield:

: 122223-69-2
1-isopropyl-2-methyl-3-(hydroxymethyl)-4-(4-fluorophenyl)-1H-pyrrole

: 122485-75-0
methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; triethylamine; In diethyl ether;
DOI:10.1021/jm00163a011

Reference yield:

: 122223-68-1
1-isopropyl-2-methyl-3-(methoxycarbonyl)-4-(4-fluorophenyl)-1H-pyrrole

: 122485-75-0
methyl 5(RS)-hydroxy-3-oxo-7-<1-isopropyl-2-methyl-4-(4-fluorophenyl)-1H-pyrrol-3-yl>hept-6(E)-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium aluminum hydride / diethyl ether / 1.) 0 deg C, 1 h, 2.) RT, 2 h

2: manganese dioxide, triethylamine / diethyl ether / 48 h / Ambient temperature

With manganese(IV) oxide; lithium aluminium tetrahydride; triethylamine; In diethyl ether;
DOI:10.1021/jm00163a011