3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

Base Information

Chemical Name:3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol
CAS No.:1202273-81-1
Molecular Formula:C₂₅H₂₇N₃O₂
Molecular Weight:401.508
Hs Code.:

Synonyms:3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

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Chemical Property of 3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

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Technology Process of 3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

There total 4 articles about 3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1202273-79-7
3-imidazol-1-yl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]-2,2-dimethylpropionic acid methyl ester

: 1202273-81-1
3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm200695m

Reference yield:

: methyl 3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionate

: 1202273-81-1
3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on activated charcoal / ethanol / 0.5 h

2: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

3: 1,1'-carbonyldiimidazole / acetonitrile / Reflux

4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; copper diacetate; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1202273-92-4
3-hydroxy-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]-2,2-dimethylpropionic acid methyl ester

: 1202273-81-1
3-(1H-imidazol-1-yl)-2,2-dimethyl-3-[4-(6-methoxynaphthalen-2-ylamino)phenyl]propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-carbonyldiimidazole / acetonitrile / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

With lithium aluminium tetrahydride; 1,1'-carbonyldiimidazole; In tetrahydrofuran; acetonitrile;