(3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene

Base Information

• Chemical Name: (3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene
• CAS No.: 1427217-92-2
• Molecular Formula: C₃₁H₃₀FeNOP
• Molecular Weight: 519.406
• Mol file: 1427217-92-2.mol

Synonyms:(3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene

Chemical Property of (3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene

There total 2 articles about (3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N,N-dimethylaminomethylferrocene (1271-86-9) + (3-bromophenyl)-diphenylphosphine oxide (10212-04-1) → (3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene (1427217-92-2)

Guidance literature:

N,N-dimethylaminomethylferrocene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere; Schlenk technique;

With zinc(II) chloride; In tetrahydrofuran; at 0 - 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

(3-bromophenyl)-diphenylphosphine oxide; With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; In tetrahydrofuran; for 20h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/om400117n

Reference yield:

C13H15BrClFeNZn + (3-bromophenyl)-diphenylphosphine oxide (10212-04-1) → (3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene (1427217-92-2) + C31H29BrFeNOP + C31H30FeNOP + 1-(3-(diphenylphosphine oxide-P-yl)phenyl)-1’-bromo-2-N,N-dimethylaminomethylferrocene

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; In tetrahydrofuran; for 20h; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1021/om400449v

Reference yield: 96.0%

(3-diphenylphosphine oxide)phenyl-2-N,N-dimethylaminomethylferrocene (1427217-92-2) → (3-diphenylphosphino)phenyl-2-N,N-dimethylaminomethylferrocene (1427217-99-9)

Guidance literature:

With trichlorosilane; triethylamine; In toluene; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1021/om400117n

upstream raw materials:

N,N-dimethylaminomethylferrocene

(3-bromophenyl)-diphenylphosphine oxide

Downstream raw materials:

(3-diphenylphosphino)phenyl-2-N,N-dimethylaminomethylferrocene

Refernces

• 1、 Madalska, Martyna,Loennecke, Peter,Ivanovski, Vladimir,Hey-Hawkins, Evamarie. "Synthesis of 1,1′,2-trisubstituted aryl-based ferrocenyl phosphines as precursors for immobilized ligands". . p. 5852 - 5861. Retrieved 2013/11/19.