1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

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Chemical Name:1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one
CAS No.:647839-17-6
Molecular Formula:C₃₂H₅₄N₂O₇Si₂
Molecular Weight:634.961
Hs Code.:

1-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1<i>H</i>-pyrimidin-2-one

Synonyms:1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

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Chemical Property of 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

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Technology Process of 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

There total 3 articles about 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 647839-16-5
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 647839-17-6
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

Guidance literature:: 1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione; With 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; at 20 ℃;

2.6-dimethylphenol; With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/jo035246b

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 647839-17-6
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 20 °C

2.2: 89 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 3 h / 20 °C

With 1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035246b

Reference yield:

: 223777-15-9
2'-O-(2-methoxyethyl)uridine

: 647839-17-6
1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2-methoxy-ethoxy)-tetrahydro-furan-2-yl]-4-(2,6-dimethyl-phenoxy)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / imidazole / dimethylformamide / 12 h / 20 °C

2.1: aq. Na₂CO₃; tetrabutylammonium bromide; 2,4,6-triisopropylbenzenesulfonyl chloride / CH₂Cl₂ / 20 °C

2.2: 89 percent / Et₃N; 1,4-diazabicyclo[2,2,2]octane / acetonitrile / 3 h / 20 °C

With 1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035246b