Carmetizide

Base Information

• Chemical Name: Carmetizide
• CAS No.: 42583-55-1
• Molecular Formula: C₁₀H₁₂ClN₃O₆S₂
• Molecular Weight: 369.807
• Mol file: 42583-55-1.mol

Synonyms:2H-1,2,4-Benzothiadiazine-3-carboxylicacid, 6-chloro-3,4-dihydro-2-methyl-7-sulfamoyl-, methyl ester, 1,1-dioxide(7CI); Carmetizide; DU 5747

Chemical Property of Carmetizide

Chemical Property:

• Vapor Pressure: 7.19E-14mmHg at 25°C
• Refractive Index: 1.6100 (estimate)
• Boiling Point: 589.4°Cat760mmHg
• Flash Point: 310.3°C
• Density: 1.618g/cm³

Purity/Quality:

99% ^*data from raw suppliers

CARMETIZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carmetizide

There total 9 articles about Carmetizide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Chlor-2.4-bis-methylsulfamoyl-anilin (1027-12-9) → 6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid (42583-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) (heating in H₂O), (ii) /BRN= 2009378/

2: (i) ClSO₃H, (ii) liq. NH₃

3: (i) (heating in H₂O), (ii) /BRN= 2705446/

4: aq. HCl, 2,2-dimethoxy-propane / 20 h / 50 °C

With hydrogenchloride; 2,2-dimethoxy-propane;

DOI:10.1021/jo01067a097

Reference yield:

6-chloro-2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (89813-57-0) → 6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid (42583-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH

2: (i) (heating in H₂O), (ii) /BRN= 2705446/

3: aq. HCl, 2,2-dimethoxy-propane / 20 h / 50 °C

With hydrogenchloride; sodium hydroxide; 2,2-dimethoxy-propane;

DOI:10.1021/jo01067a097

Reference yield:

6-chloro-2-methyl-1,1,3-trioxo-1,2,3,4-tetrahydro-1λ6-benzo[1,2,4]thiadiazine-7-sulfonic acid methylamide (135-08-0) → 6-Chlor-3.4-dihydro-3-methoxycarbonyl-2-methyl-7-sulfamoyl-2H-1.2.4-benzothiadiazin-1.1-dioxid (42583-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) ClSO₃H, (ii) SOCl₂, (iii) liq. NH₃

2: aq. NaOH

3: (i) (heating in H₂O), (ii) /BRN= 2705446/

4: aq. HCl, 2,2-dimethoxy-propane / 20 h / 50 °C

With hydrogenchloride; sodium hydroxide; 2,2-dimethoxy-propane;

DOI:10.1021/jo01067a097

upstream raw materials:

diazomethane

6-chloro-1,1-dioxo-7-sulfamoyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid

6-chloro-2-methyl-1,1-dioxo-7-sulfamoyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid

methanol

Downstream raw materials:

1-(6-chloro-2-methyl-1,1-dioxo-7-sulfamoyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carbonyl)-4-(2-methoxy-phenyl)-piperazine

6-chloro-2-methyl-1,1-dioxo-7-sulfamoyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid 6-[4-(2-methoxy-phenyl)-piperazin-1-yl]-hexylamide

6-chloro-2-methyl-1,1-dioxo-7-sulfamoyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-3-carboxylic acid benzylamide

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