Technology Process of C14H16F2N2O3*ClH
There total 16 articles about C14H16F2N2O3*ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-((2-(4-difluoromethoxy-3-isopropoxyphenyl)oxazol-4-yl)methyl)isoindoline-1,3-dione;
With
methylamine;
In
methanol; water;
for 0.5h;
Reflux;
With
cyclopentyl methyl ether; sodium hydroxide;
In
methanol; water;
at 65 - 75 ℃;
With
hydrogenchloride;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 20 °C
1.2: 2 h / 0 °C
2.1: 3-chloro-2-oxopropyl acetate / toluene / 22 h / Molecular sieve; Reflux
2.2: 0.25 h / Reflux
3.1: triethylamine; methanesulfonyl chloride / ethyl acetate / 1 h / 20 °C
3.2: 1 h / 30 °C
4.1: N,N-dimethyl-formamide / 1 h / 80 °C
5.1: methylamine / water; methanol / 0.5 h / Reflux
With
3-chloro-2-oxopropyl acetate; methanesulfonyl chloride; triethylamine; 1,1'-carbonyldiimidazole; methylamine;
In
methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 3-chloro-2-oxopropyl acetate / toluene / 22 h / Molecular sieve; Reflux
1.2: 0.25 h / Reflux
2.1: triethylamine; methanesulfonyl chloride / ethyl acetate / 1 h / 20 °C
2.2: 1 h / 30 °C
3.1: N,N-dimethyl-formamide / 1 h / 80 °C
4.1: methylamine / water; methanol / 0.5 h / Reflux
With
3-chloro-2-oxopropyl acetate; methanesulfonyl chloride; triethylamine; methylamine;
In
methanol; water; ethyl acetate; N,N-dimethyl-formamide; toluene;