159783-48-9

Upstream product

• 151103-08-1 4-difluoromethoxy-3-hydroxybenzaldehyde 
• 159783-82-1 4-Difluoromethoxy-3-(1-methyl)ethoxybenzaldehyde 
• 71118-98-4 4-hydroxy-3-isopropoxybenzaldehyde 
• 1002984-09-9 ethyl 4-(benzyloxy)-3-isopropoxybenzoate 
• 177429-27-5 ethyl 4-benzyloxy-3-hydroxybenzoate 
• 1895-39-2 sodium chlorodifluoroacetate 

Downstream Products

• 1574285-36-1 C₁₄H₁₅F₂NO₄ 
• 1574285-38-3 C₁₄H₁₄BrF₂NO₃ 
• 1574285-40-7 2-((2-(4-difluoromethoxy-3-isopropoxyphenyl)oxazol-4-yl)methyl)isoindoline-1,3-dione 
• 1574285-43-0 C₁₄H₁₆F₂N₂O₃*ClH 
• 937782-05-3 N-({2-[4-(difluoromethoxy)-3-isopropoxyphenyl]oxazole-4-yl}methyl)-2-ethoxybenzamide 

Relevant academic research and scientific papers

METHOD FOR PRODUCING OXAZOLE COMPOUND

An object of the present invention is to provide a novel method for producing an oxazole compound. The invention relates to a method for producing a compound represented by formula (1): wherein R1 is lower alkyl group or halogen substituted lower alkyl group, R2 is lower alkyl group, R5 is lower alkyl group, R11 is lower alkyl group, halogen substituted lower alkyl group or a group represented by formula: -CY2COOR12, wherein Y is a halogen atom, R12 is an alkali metal atom or lower alkyl group, Ar1 is phenyl group substituted with lower alkyl group, etc., or pyridyl group substituted with lower alkyl group, etc., X2, X3 and X9 are the same or different and are halogen atoms, X4 is a leaving group, and M is an alkali metal atom.

FLUOROALKOXY-SUBSTITUTED BENZAMIDES AND THEIR USE AS CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITORS

Compounds of formula (I), in which one of the substituents R1 or R2 stands for hydrogen, 1-6C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, benzyloxy or totally or partially fluorine-substituted 1-4C-alkoxy, and the other stands for totally or partially fluorine-substituted 1-4C-alkoxy, and R3 stands for phenyl, pyridyl, R31, R32 and R33-substituted phenyl or R34, R35, R36 and R37-substituted pyridyl, in which R31 stands for hydroxy, halogen, cyano, carboxyl, trifluoromethyl 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-atkylamino or 1-4C-alkylcarbonylamino; R32 stands for hydrogen, hydroxy, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy; R33 stands for hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy; R34 stands for hydroxy, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino; R35 stands for hydrogen, halogen, amino or 1-4C-alkyl; R36 stands for hydrogen or halogen; and R37 stands for hydrogen or halogen. These compounds constitute new effective bronchotherapeutic drugs