Technology Process of Chloro-methanesulfonic acid (2R,4S,5R)-2-phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-ylmethyl ester
There total 13 articles about Chloro-methanesulfonic acid (2R,4S,5R)-2-phenyl-5-((4R,5S)-2-phenyl-4-vinyl-[1,3,2]dioxaborinan-5-yloxy)-[1,3]dioxan-4-ylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
dichloromethane;
at 21 - 23 ℃;
DOI:10.1055/s-2002-33527
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: Amberlyst 15 / methanol / 24 h / Heating
2.1: Amberlyst 15 / CHCl3 / 22.5 h
3.1: 100 percent / aq. OsO4; NMO / dioxane / 96 h / 20 °C
4.1: 100 percent / 2,6-lutidine / CH2Cl2 / 72 h / 0 - 22 °C
5.1: DIBALH / CH2Cl2 / 0.2 h / -78 °C
6.1: aq. HCl / CH2Cl2 / 16 h / 22 °C
7.1: t-BuLi / tetrahydrofuran / 0.33 h / -78 °C
7.2: 79 percent / tetrahydrofuran / 1 h / -78 °C
8.1: 100 percent / TBAF / tetrahydrofuran / 22 °C
9.1: aq. NaIO4 / dioxane / 22 °C
10.1: NaBH4 / methanol / 0 °C
11.1: 95 percent / benzene / Heating
12.1: 100 percent / 2,6-lutidine / CH2Cl2 / 21 - 23 °C
With
2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; Amberlyst 15; tetrabutyl ammonium fluoride; tert.-butyl lithium; diisobutylaluminium hydride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; benzene;
DOI:10.1055/s-2002-33527
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: Amberlyst 15 / CHCl3 / 22.5 h
2.1: 100 percent / aq. OsO4; NMO / dioxane / 96 h / 20 °C
3.1: 100 percent / 2,6-lutidine / CH2Cl2 / 72 h / 0 - 22 °C
4.1: DIBALH / CH2Cl2 / 0.2 h / -78 °C
5.1: aq. HCl / CH2Cl2 / 16 h / 22 °C
6.1: t-BuLi / tetrahydrofuran / 0.33 h / -78 °C
6.2: 79 percent / tetrahydrofuran / 1 h / -78 °C
7.1: 100 percent / TBAF / tetrahydrofuran / 22 °C
8.1: aq. NaIO4 / dioxane / 22 °C
9.1: NaBH4 / methanol / 0 °C
10.1: 95 percent / benzene / Heating
11.1: 100 percent / 2,6-lutidine / CH2Cl2 / 21 - 23 °C
With
2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; Amberlyst 15; tetrabutyl ammonium fluoride; tert.-butyl lithium; diisobutylaluminium hydride;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; benzene;
DOI:10.1055/s-2002-33527
