Technology Process of (S)-tert-butyl 2-(4-methylpent-1-en-3-ylamino)phenylcarbamate
There total 7 articles about (S)-tert-butyl 2-(4-methylpent-1-en-3-ylamino)phenylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 80 °C
2.1: thionyl chloride / 0 °C
3.1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere
5.1: sodium hydrogencarbonate / ethanol / 1 h / 0 - 20 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
6.2: 1 h / -78 °C
7.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C
With
lithium borohydride; thionyl chloride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
6.1: |Swern Oxidation / 6.2: |Swern Oxidation / 7.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
1.2: 1 h / -78 °C
2.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C
With
oxalyl dichloride; methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation / 2.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere
3.1: sodium hydrogencarbonate / ethanol / 1 h / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
4.2: 1 h / -78 °C
5.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C
With
lithium borohydride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; sodium hydrogencarbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
4.1: |Swern Oxidation / 4.2: |Swern Oxidation / 5.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837
