Technology Process of (E)-1-(4-fluorobenzyl)-4-isopropyl-2,3-dihydro-1H-1,5-benzodiazepine
There total 9 articles about (E)-1-(4-fluorobenzyl)-4-isopropyl-2,3-dihydro-1H-1,5-benzodiazepine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-tert-butyl 2-(4-methylpent-1-en-3-ylamino)phenylcarbamate;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 0.333333h;
4-fluorobenzaldehyde;
In
dichloromethane;
at 20 ℃;
DOI:10.1055/s-0033-1340837
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C
2.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
2.2: 20 °C
With
methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
1.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 80 °C
2.1: thionyl chloride / 0 °C
3.1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere
5.1: sodium hydrogencarbonate / ethanol / 1 h / 0 - 20 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
6.2: 1 h / -78 °C
7.1: potassium hexamethylsilazane; methyl-triphenylphosphonium iodide / tetrahydrofuran / 1 h / -78 - 20 °C
8.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 - 20 °C
8.2: 20 °C
With
lithium borohydride; thionyl chloride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; methyl-triphenylphosphonium iodide; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
6.1: |Swern Oxidation / 6.2: |Swern Oxidation / 7.1: |Wittig Olefination;
DOI:10.1055/s-0033-1340837
