2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

Base Information

Chemical Name:2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile
CAS No.:1392426-80-0
Molecular Formula:C₁₈H₁₉N₃O₂S
Molecular Weight:341.434
Hs Code.:

Synonyms:2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

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Chemical Property of 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

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Technology Process of 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

There total 7 articles about 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1392426-84-4
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

: 1392426-80-0
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

Guidance literature:: With Burgess Reagent; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c2ob00034b

Reference yield:

: 227017-79-0
N-(1,3-benzodioxol-5-ylmethyl)cyclohexanamine

: 1392426-80-0
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1,4-dioxane / 168 h / 130 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h / 40 °C / Inert atmosphere

3: thionyl chloride / N,N-dimethyl-formamide; toluene / 1.5 h / 25 - 80 °C

4: ammonia / methanol; toluene / 1 h / 0 - 25 °C / Inert atmosphere

5: Burgess Reagent / dichloromethane / 2 h / 25 °C / Inert atmosphere

With thionyl chloride; Burgess Reagent; lithium hydroxide monohydrate; ammonia; water; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2ob00034b

Reference yield:

: 1392426-83-3
ethyl 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxylate

: 1392426-80-0
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h / 40 °C / Inert atmosphere

2: thionyl chloride / N,N-dimethyl-formamide; toluene / 1.5 h / 25 - 80 °C

3: ammonia / methanol; toluene / 1 h / 0 - 25 °C / Inert atmosphere

4: Burgess Reagent / dichloromethane / 2 h / 25 °C / Inert atmosphere

With thionyl chloride; Burgess Reagent; lithium hydroxide monohydrate; ammonia; water; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2ob00034b