2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide
CAS No.:1392426-84-4
Molecular Formula:C₁₈H₂₁N₃O₃S
Molecular Weight:359.449
Hs Code.:

Synonyms:2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

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Chemical Property of 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

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Technology Process of 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

There total 6 articles about 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392426-95-7
C₁₈H₁₉ClN₂O₃S

: 1392426-84-4
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

Guidance literature:: With ammonia; In methanol; toluene; at 0 - 25 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2ob00034b

Reference yield:

: 227017-79-0
N-(1,3-benzodioxol-5-ylmethyl)cyclohexanamine

: 1392426-84-4
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-dioxane / 168 h / 130 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h / 40 °C / Inert atmosphere

3: thionyl chloride / N,N-dimethyl-formamide; toluene / 1.5 h / 25 - 80 °C

4: ammonia / methanol; toluene / 1 h / 0 - 25 °C / Inert atmosphere

With thionyl chloride; lithium hydroxide monohydrate; ammonia; water; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2ob00034b

Reference yield:

: 1392426-83-3
ethyl 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxylate

: 1392426-84-4
2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 5 h / 40 °C / Inert atmosphere

2: thionyl chloride / N,N-dimethyl-formamide; toluene / 1.5 h / 25 - 80 °C

3: ammonia / methanol; toluene / 1 h / 0 - 25 °C / Inert atmosphere

With thionyl chloride; lithium hydroxide monohydrate; ammonia; water; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c2ob00034b