(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

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Chemical Name:(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one
CAS No.:256409-76-4
Molecular Formula:C₃₉H₃₄N₂O₅
Molecular Weight:610.709
Hs Code.:

Synonyms:(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

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Chemical Property of (3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

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Technology Process of (3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

There total 8 articles about (3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 33375-06-3
(1R)-1-phenylethyl isocyanate

: 256418-88-9
(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]azetidin-2-one

: 256409-76-4
(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/S0968-0896(01)00209-7

Reference yield:

: 100-39-0
benzyl bromide

: 256409-76-4
(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; heptane; ethylbenzene / 0.33 h / -55 °C

1.2: 98 percent / tetrahydrofuran; heptane; ethylbenzene / 1.5 h / -40 - -15 °C

2.1: dimethylformamide; acetic acid / 0.67 h / 50 - 55 °C

3.1: 53 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 25 °C

4.1: 74 percent / aq. NaOH / acetone / 3 h / 10 - 15 °C

5.1: 83 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 20 °C

With dmap; sodium hydroxide; tetrabutyl ammonium fluoride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(01)00209-7

Reference yield:

: 908093-98-1
diazodiphenylmethane

: 256409-76-4
(3S,4S)-3-benzyl-4-[4-(1,1-diphenylmethoxycarbonyl)phenoxy]-1-[(R)-1-(phenylethyl)aminocarbonyl]azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / CH₂Cl₂; methanol / 16 h / 20 °C

2: 74 percent / aq. NaOH / acetone / 3 h / 10 - 15 °C

3: 83 percent / Et₃N; DMAP / CH₂Cl₂ / 16 h / 20 °C

With dmap; sodium hydroxide; triethylamine; In methanol; dichloromethane; acetone;
DOI:10.1016/S0968-0896(01)00209-7