(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

Base Information

Chemical Name:(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde
CAS No.:118100-81-5
Molecular Formula:C₂₁H₂₄O₃
Molecular Weight:324.42
Hs Code.:

Synonyms:(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

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Technology Process of (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

There total 10 articles about (R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 188416-16-2
(R)-(+)-6-benzyloxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-ylmethanol

: 118100-81-5
(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;
DOI:10.1016/S0040-4039(02)01865-8

Reference yield: 79.0%

: 918876-45-6
benzyl (R)-6-(benzyloxy)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylate

: 118100-81-5
(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

Guidance literature:: With diisobutylaluminium hydride; In hexane; n-heptane; at -78 ℃; for 2.5h;
DOI:10.1016/j.tet.2006.09.082

Reference yield:

: 100-39-0
benzyl bromide

: 118100-81-5
(R)-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / sodium hydride / tetrahydrofuran / 20 h / 20 °C

2: 97 percent / oxalyl chloride; dimethylsulfoxide; triethylamine / CH₂Cl₂ / 4.5 h / -78 °C

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1016/j.bmc.2006.03.035