7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

Base Information

Chemical Name:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide
CAS No.:109774-31-4
Molecular Formula:C₁₉H₁₈ClFN₄O₂
Molecular Weight:388.829
Hs Code.:

Synonyms:7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

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Chemical Property of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

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Technology Process of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

There total 4 articles about 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 109774-13-2
7-chloro-5-(2-fluorophenyl)-alpha-hydroxyimino-N,N-dimethyl-3H-1,4-benzodiazepine-2-acetamide

: 109774-31-4
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

Guidance literature:: With sodium tetrahydroborate; ethanol; for 48h; Ambient temperature;
DOI:10.1002/jhet.5570230509

Reference yield:

: 109773-98-0
<7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene>N,N-dimethylacetamide 4-oxide

: 109774-31-4
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₃ / CH₂Cl₂ / 0.5 h

2: 70 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

3: 50 percent / sodium borohydride, ethanol / 48 h / Ambient temperature

With sodium tetrahydroborate; ethanol; acetic acid; sodium nitrite; phosphorus trichloride; In dichloromethane;
DOI:10.1002/jhet.5570230509

Reference yield:

: 60656-74-8
6-chloro-2-chloromethyl-4-(2-fluoro-phenyl)-quinazoline 3-oxide

: 109774-31-4
7-chloro-5-(2-fluorophenyl)-2,3-dihydro-alpha-(hydroxyimino)-N,N-dimethyl-1H-1,4-benzodiazepine-2-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1) lithium diisopropylamide / 1) hexane, tetrahydrofuran, below -50 deg C 2) warming to room temperature, 1 h

2: PCl₃ / CH₂Cl₂ / 0.5 h

3: 70 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

4: 50 percent / sodium borohydride, ethanol / 48 h / Ambient temperature

With sodium tetrahydroborate; ethanol; acetic acid; lithium diisopropyl amide; sodium nitrite; phosphorus trichloride; In dichloromethane;
DOI:10.1002/jhet.5570230509