N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

Base Information

Chemical Name:N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine
CAS No.:1160683-95-3
Molecular Formula:C₂₃H₁₅F₂N₃O₄
Molecular Weight:435.387
Hs Code.:

Synonyms:N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

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Chemical Property of N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

Chemical Property:

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Technology Process of N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

There total 8 articles about N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1160682-81-4
ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

: 98-80-6
phenylboronic acid

: 1160683-95-3
N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate; phenylboronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 120 ℃; for 0.333333h; Microwave irradiation;

With water; sodium hydroxide; In 1,4-dioxane; methanol; at 20 ℃; for 0.25h;

With hydrogenchloride; In 1,4-dioxane; methanol; water;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160683-95-3
N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

5.2: 0.33 h / 100 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20 °C

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 120 °C / Microwave irradiation

8.2: 0.25 h / 20 °C

With ammonium hydroxide; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; bromine; nitric acid; boron tribromide; sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160683-95-3
N-{[3-(3,4-difluorophenyl)-6-hydroxy-7-phenyl-5-quinoxalinyl]carbonyl}glycine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

3.2: 0.33 h / 100 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

6.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.33 h / 120 °C / Microwave irradiation

6.2: 0.25 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; bromine; boron tribromide; sodium hydride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; ethyl acetate; mineral oil;