ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Base Information

Chemical Name:ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate
CAS No.:1160682-81-4
Molecular Formula:C₁₉H₁₄BrF₂N₃O₄
Molecular Weight:466.239
Hs Code.:

Synonyms:ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

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Chemical Property of ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

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Technology Process of ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

There total 7 articles about ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1160682-80-3
7-Bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinecarboxylic acid

: 623-33-6
glycine ethyl ester hydrochloride

: 1160682-81-4
ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1160682-81-4
ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid; nitric acid / 0 - 20 °C

2.1: ammonium hydroxide / ethanol; water / 20 °C

3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

4.1: bromine / dichloromethane / 0.5 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

5.2: 0.33 h / 100 °C / Microwave irradiation

6.1: boron tribromide / dichloromethane / 20 °C

7.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

With ammonium hydroxide; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; bromine; nitric acid; boron tribromide; sodium hydride; triethylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate; mineral oil;

Reference yield:

: 346691-23-4
methyl 2-amino-6-fluoro-3-nitrobenzoate

: 1160682-81-4
ethyl N-{[7-bromo-3-(3,4-difluorophenyl)-6-hydroxy-5-quinoxalinyl]carbonyl}glycinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C

2.1: bromine / dichloromethane / 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

3.2: 0.33 h / 100 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; bromine; boron tribromide; sodium hydride; triethylamine; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; mineral oil;