ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

Base Information

Chemical Name:ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate
CAS No.:1394232-49-5
Molecular Formula:C₂₅H₂₇N₃O₅
Molecular Weight:449.506
Hs Code.:

Synonyms:ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

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Chemical Property of ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

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Technology Process of ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

There total 3 articles about ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 931-53-3
Cyclohexyl isocyanide

: 93634-60-7,93913-55-4
(Z)-ethyl 2-benzamido-3-(4-nitrophenyl)acrylate

: 1394232-49-5
ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

Guidance literature:: at 175 ℃; for 1.5h; diastereoselective reaction; Neat (no solvent);
DOI:10.1016/j.tet.2012.06.073

Reference yield:

: 495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2
Hippuric Acid

: 1394232-49-5
ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; acetic anhydride

2: sodium ethanolate

3: 1.5 h / 175 °C / Neat (no solvent)

With sodium ethanolate; sodium acetate; acetic anhydride; 1: Erlenmeyer-Plochl azlactone and amino acid synthesis;
DOI:10.1016/j.tet.2012.06.073

Reference yield:

: 7152-75-2,57427-80-2,57427-96-0
(Z)-2-phenyl-4-(4-nitrobenzylidene)-(4H)-1,3-oxazol-5-one

: 1394232-49-5
ethyl (5Z)-5-(cyclohexylimino)-4-(4-nitrobenzyl)-2-phenyl-4,5-dihydro-1,3-oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium ethanolate

2: 1.5 h / 175 °C / Neat (no solvent)

With sodium ethanolate;
DOI:10.1016/j.tet.2012.06.073