(+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide

Base Information

• Chemical Name: (+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide
• CAS No.: 97551-07-0
• Molecular Formula: C₃₀H₂₄N₂O
• Molecular Weight: 428.533

Synonyms:(+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide

Chemical Property of (+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide

Chemical Property:

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Technology Process of (+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide

There total 2 articles about (+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(S)-2,2'-bis(bromomethyl)-1,1'-binaphthyl (37803-02-4) + (-)-α-aminophenylacetamide (6485-67-2) → (+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide (97551-07-0)

Guidance literature:

With triethylamine; In acetonitrile; benzene; for 10h; Heating;

DOI:10.1021/jo00220a046

Reference yield:

2,2'-di(bromomethyl)-1,1'-binaphthalene (54130-90-4,86631-56-3,37803-02-4) + (-)-α-aminophenylacetamide (6485-67-2) → (-)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide (97590-56-2) + (+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide (97551-07-0)

Guidance literature:

With triethylamine; In acetonitrile; benzene; for 10h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jo00220a046

Reference yield: 94.0%

(+)-α-<4,5-dihydro-3H-dinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetamide (97551-07-0) → (+)-α-<2,7-dihydrodinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetonitrile (97551-08-1)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1021/jo00220a046

upstream raw materials:

2,2'-di(bromomethyl)-1,1'-binaphthalene

(-)-α-aminophenylacetamide

(S)-2,2'-bis(bromomethyl)-1,1'-binaphthyl

Downstream raw materials:

(+)-α-<2,7-dihydrodinaphtho<2,1-c:1',2'-e>azepinyl>-α-phenylacetonitrile

2-(3,5-Dihydro-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-3-hydroxy-4-methyl-2-phenyl-pentanenitrile

2-(3,5-Dihydro-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-3-hydroxy-2,4-diphenyl-butyronitrile

2-(3,5-Dihydro-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-3-hydroxy-2-phenyl-hexanenitrile

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