N^α-Boc 4--L-phenylalanine benzyl ester

Base Information

Chemical Name:N^α-Boc 4--L-phenylalanine benzyl ester
CAS No.:150618-03-4
Molecular Formula:C₂₆H₃₄F₂NO₇P
Molecular Weight:541.529
Hs Code.:

N<sup>α</sup>-Boc 4-<diethyl phosphono(difluoromethyl)>-L-phenylalanine benzyl ester

Synonyms:N^α-Boc 4--L-phenylalanine benzyl ester

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Chemical Property of N^α-Boc 4--L-phenylalanine benzyl ester

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Technology Process of N^α-Boc 4--L-phenylalanine benzyl ester

There total 11 articles about N^α-Boc 4--L-phenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 150618-09-0
(S)-2-tert-Butoxycarbonylamino-3-[4-(diethoxy-phosphoranecarbonyl)-phenyl]-propionic acid benzyl ester

: 150618-03-4
N^α-Boc 4--L-phenylalanine benzyl ester

Guidance literature:: With diethylamino-sulfur trifluoride; for 1h; Ambient temperature;
DOI:10.1016/S0040-4039(00)73631-8

Reference yield: 30.0%

: (R)-(3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-3-oxopropyl)zinc(II) iodide

: 156017-41-3
[Difluoro-(4-iodo-phenyl)-methyl]-phosphonic acid diethyl ester

: 150618-03-4
N^α-Boc 4--L-phenylalanine benzyl ester

Guidance literature:: With zinc copper; dichlorobis(tri-O-tolylphosphine)palladium; 2,4-dichlorophenoxyacetic acid dimethylamine; In toluene; at 50 ℃; for 18h;
DOI:10.1016/S0040-4039(99)00266-X

Reference yield:

: 59524-02-6
N-tert-butoxycarbonyl-L-serine benzyl ester

: 150618-03-4
N^α-Boc 4--L-phenylalanine benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / -5 °C

2: NaI / acetone / Ambient temperature

3: 1.) zinc dust, 2.) diethyl 4-phosphono(difluoromethyl)iodobenzene / 2.) (Ph₃P)2PdCl₂ / 1.) THF/N,N-dimethylacetamide, 65 deg C, 1 h, 2.) THF/N,N-dimethylacetamide, 65 deg C, 5 h

With pyridine; diethyl 4-phosphono(difluoromethyl)iodobenzene; sodium iodide; zinc; bis-triphenylphosphine-palladium(II) chloride; In acetone;
DOI:10.1016/S0040-4039(00)75835-7