156017-41-3

Usage

Uses

Used in Organic Synthesis:
Phosphonic acid, [difluoro(4-iodophenyl)methyl]-, diethyl ester is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique functional group allows for versatile reactions and the formation of diverse chemical structures.
Used in Pharmaceutical Production:
In the pharmaceutical industry, Phosphonic acid, [difluoro(4-iodophenyl)methyl]-, diethyl ester is utilized as a key intermediate in the synthesis of various drugs. Its unique structure contributes to the development of new therapeutic agents with potential applications in treating a wide range of diseases.
Used in Agrochemical Development:
Phosphonic acid, [difluoro(4-iodophenyl)methyl]-, diethyl ester also finds use in the agrochemical sector, where it serves as a precursor for the synthesis of pesticides and other crop protection agents. Its incorporation into these products can enhance their effectiveness and selectivity, leading to improved agricultural outcomes.
Used in Medicinal Chemistry and Drug Discovery:
Due to its unique structure and reactivity, Phosphonic acid, [difluoro(4-iodophenyl)methyl]-, diethyl ester holds potential in the field of medicinal chemistry and drug discovery. Researchers can leverage its properties to design and develop novel compounds with therapeutic potential, contributing to the advancement of medical treatments.
Used in Material Science:
In addition to its applications in chemical synthesis and pharmaceuticals, Phosphonic acid, [difluoro(4-iodophenyl)methyl]-, diethyl ester may also be utilized in the development of new materials and chemical intermediates. Its unique properties can contribute to the creation of innovative materials with specific characteristics, such as improved stability or reactivity, for use in various industries.

Upstream product

• 624-38-4 para-diiodobenzene 
• 82845-20-3 [(diethoxyphosphoryl)difluoromethyl]zinc bromide 
• 5122-99-6 4-iodophenylboronic acid 
• 80077-72-1 diethyl difluoro(trimethylsilyl)methylphosphonate 
• 1711-02-0 4-iodobenzoic acid chloride 
• 173443-43-1 diethyl (4-iodobenzyl)phosphonate 
• 65094-22-6 diethyl (bromodifluoromethyl)phosphonate 
• 156017-40-2 diethyl (4-iodobenzoyl)phosphonate 

Downstream Products

• 156017-43-5 (2S)-{4-[2-tert-butoxycarbonylamino-2-(methoxycarbonyl)-ethyl]-phenyl}difluoromethyl-phosphonic acid diethyl ester 
• 156017-44-6 Fmoc-(4-diethyl phosphonodifluoromethyl)-Phe-OMe 
• 150618-03-4 N^α-Boc 4--L-phenylalanine benzyl ester 
• 189393-74-6 [Difluoro-(4-formyl-phenyl)-methyl]-phosphonic acid diethyl ester 
• 156017-45-7 (S)-2-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-3-{4-[(diethoxyphosphoryl)difluoromethyl]phenyl}propanoic acid 
• 150618-05-6 (2S)-2-[(tert-butoxycarbonyl)amino]-3-{4-[(diethoxyphosphoryl)(difluoro)methyl]phenyl}propanoic acid 
• 222544-96-9 2-{4'-[(Diethoxyphosphoryl)difluoromethyl]phenyl}-5-(1,3-dioxolan-2-yl)furan 

Relevant academic research and scientific papers

Electrolytic partial fluorination of organic compounds 84. Anodic mono- and difluorination of benzylphosphonate derivatives

Anodic fluorination of benzylphosphonate derivatives was carried out under various electrolytic conditions to provide the corresponding α-mono- and/or α,α-difluoro-products in moderate to good yields. It was found that the selectivity of fluorinated produ

Copper-mediated oxidative difluoromethylenation of aryl boronic acids with α-silyldifluoromethylphosphonates: A new method for aryldifluorophosphonates

An unprecedented copper-mediated oxidative difluoromethylenation of aryl boronic acids with α-silyldifluoromethylphosphonates has been developed, allowing rapid access to a wide range of aryldifluorophosphonates containing various functional groups. This method provides a complementary and alternative method to Cu-mediated cross-couplings of aryl iodides with metalated difluoromethylphosphonates.

Facile syntheses of aryldifluorophosphonate building blocks

The copper-catalysed zinc phosphonate chemistry described by Yokomatsu and Shibuya can be used directly in the synthesis of phosphotyrosine analogue F2Pmp, and in entering the classical organometallic coupling repertoire via Stille and Suzuki-M

Synthesis and biological evaluation of α,α-difluorobenzylphosphonic acid derivatives as small molecular inhibitors of protein-tyrosine phosphatase 1B

A series of α,α-difluorobenzylphosphonic acids having a hydrophobic functional group were prepared via the Stille coupling reaction from halogenated α,α-difluorobenzylphosphonates. Evaluation of inhibitory activity toward protein tyrosine phosphatase (PTP 1B) revealed that the ethynyl, phenylethynyl and (E)-styryl groups on the benzene nuclei increased the inhibitory activity of α,α-difluorobenzylphosphonic acid. Inhibitory activities significantly increased upon introducing both (E)-styryl and bis- methylsulfonamide functional groups onto the benzene nuclei of α,α- difluorobenzylphosphonic acid.

Enantioselective synthesis of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine; agents suitable for the solid-phase synthesis of peptides containing nonhydrolyzable analogues of O-phosphotyrosine

Enantioselective convergent syntheses of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine are reported.