4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

Base Information

Chemical Name:4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one
CAS No.:305324-35-0
Molecular Formula:C₁₉H₂₈N₂O₄
Molecular Weight:348.442
Hs Code.:

Synonyms:4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

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Chemical Property of 4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

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Technology Process of 4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

There total 3 articles about 4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2393-23-9
4-methoxy-benzylamine

: 305324-34-9
2-((tert-butoxycarbonyl)(2-oxobutyl)amino)acetic acid

: 305324-35-0
4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

Guidance literature:: 4-methoxy-benzylamine; 2-((tert-butoxycarbonyl)(2-oxobutyl)amino)acetic acid; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 25 ℃; for 16h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 17h;
DOI:10.1002/1522-2675(20000809)83:8<1825::AID-HLCA1825>3.0.CO;2-4

Reference yield:

: 56074-21-6
N-((tert-butyloxy)carbonyl)iminodiacetic acid anhydride

: 305324-35-0
4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 39 percent / EDCI; EtN(i-Pr)2 / dimethylformamide / 10 h / 25 °C

2.1: 93 percent / tetrahydrofuran / 1 h / 25 °C

3.1: AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane / 16 h / 25 °C

3.2: 92 percent / EDCI / dimethylformamide / 17 h / 25 °C

With sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: Addition / 2.1: Grignard reaction / 3.1: Condensation / 3.2: Cyclization;
DOI:10.1002/1522-2675(20000809)83:8<1825::AID-HLCA1825>3.0.CO;2-4

Reference yield:

: 675189-36-3
2-((tert-butoxycarbonyl)(2-(methoxy(methyl)amino)-2-oxoethyl)amino)acetic acid

: 305324-35-0
4-[(tert-butoxy)carbonyl]-6-ethyl-1-[(4-methoxyphenyl)methyl]piperazin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / tetrahydrofuran / 1 h / 25 °C

2.1: AcOH; NaBH(OAc)3 / 1,2-dichloro-ethane / 16 h / 25 °C

2.2: 92 percent / EDCI / dimethylformamide / 17 h / 25 °C

With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane; 1.1: Grignard reaction / 2.1: Condensation / 2.2: Cyclization;
DOI:10.1002/1522-2675(20000809)83:8<1825::AID-HLCA1825>3.0.CO;2-4