(R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine

Base Information

• Chemical Name: (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine
• CAS No.: 1219025-14-5
• Molecular Formula: C₂₉H₂₆NP
• Molecular Weight: 419.506
• Mol file: 1219025-14-5.mol

Synonyms:(R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine

Chemical Property of (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine

There total 1 articles about (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-7'-diphenylphosphino-1,1'-spirobiindanyl-7-carboxylic acid (913829-91-1) → (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine (1219025-14-5)

Guidance literature:

(R)-7'-diphenylphosphino-1,1'-spirobiindanyl-7-carboxylic acid; With sodium azide; sulfuric acid; In chloroform; at 40 ℃; for 5.5h; Reflux;

With water; sodium hydroxide; In chloroform; at 0 ℃;

DOI:10.1021/ja100652f

Reference yield: 98.0%

(R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine (1219025-14-5) + C35H47O2P → C64H73NOP2

Guidance literature:

(R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine; C₃₅H₄₇O₂P; With acetic acid; In methanol; at 40 ℃; for 3h; Inert atmosphere; Schlenk technique;

With sodium cyanoborohydride; In methanol; at 40 ℃; for 12h; Inert atmosphere;

Reference yield: 97.0%

dimethoxyacetaldehyde (51673-84-8) + (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine (1219025-14-5) → (R)-N-(2,2-dimethoxyethyl)-7'-(diphenylphosphanyl)-1,1'-spirobiindanyl-7-amine

Guidance literature:

With sodium tris(acetoxy)borohydride; In water; 1,2-dichloro-ethane; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/anie.201502860

upstream raw materials:

(R)-7'-diphenylphosphino-1,1'-spirobiindanyl-7-carboxylic acid

Downstream raw materials:

(R)-N-(pyridyl-2-methyl)-7-diphenylphosphino-7'-amino-1,1'-spiro-dihydro-indene