51673-84-8

Basic information

• Product Name: GLYOXAL DIMETHYL ACETAL
• Synonyms: dimethoxy-acetaldehyd;glyoxal1,1-dimethylacetalsol.,~45%int-butylmethyleth.;2,2-DIMETHOXYACETALDEHYDE;DIMETHOXYACETALDEHYDE;GLYOXAL DIMETHYL ACETAL;GLYOXAL 1,1-DIMETHYL ACETAL;Glyoxal 1,1-dimethyl acetal Solution;DIMETHOXYACETALDEHYDE, 60 WT. % SOLUTION WATER
• CAS NO: 51673-84-8
• Molecular Formula: C₄H₈O₃
• Molecular Weight: 104.1
• EINECS: 421-890-0
• Mol File: 51673-84-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 100 °C
• Flash Point: 169 °F
• Appearance: /
• Density: 1.15 g/mL at 25 °C
• Vapor Pressure: 168mmHg at 25°C
• Refractive Index: n20/D 1.414
• Storage Temp.: 2-8°C
• Water Solubility: Fully miscible in water.
• BRN: 1850744
• CAS DataBase Reference: GLYOXAL DIMETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: GLYOXAL DIMETHYL ACETAL(51673-84-8)
• EPA Substance Registry System: GLYOXAL DIMETHYL ACETAL(51673-84-8)

Safety Data

• Hazard Codes: Xi,F
• Statements: 43-38-11
• Safety Statements: 24-37-36/37-16
• RIDADR: UN 2398 3/PG 2
• TSCA: Yes
• Hazardous Substances Data: 51673-84-8(Hazardous Substances Data)

Usage

Uses

Glyoxal dimethyl acetal is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuffs.

Synthesis Reference(s)

Synthetic Communications, 18, p. 1343, 1988 DOI: 10.1080/00397918808078802

General Description

This product is a 60wt% solution of 2,2-dimethoxyacetaldehyde (glyoxal dimethyl acetal) in water. The aldol condensation of 2,2-dimethoxyacetaldehyde with acetoacetic ester in the absence of the catalyst and solvent has been reported. It participates in the synthesis of isoxazoline vinyl ester pseudopeptides and tetrahydro-β-carboline derivatives of barbituric acid analogs.

InChI:InChI=1/C4H8O3/c1-6-4(3-5)7-2/h3-4H,1-2H3

Upstream product

• 67-56-1 methanol 
• 131543-46-9 Glyoxal 
• 5370-08-1 1,1,4,4-tetramethoxy-2-butene 
• 1071116-48-7 geranyl oxyacetaldehyde dimethyl acetal 
• 97-97-2 chloroacetaldehyde dimethyl acetal 
• 106-24-1 Geraniol 
• 30934-97-5 2,2-dimethoxyethanol 
• 21962-24-3 1,1-dimethoxy-2-butene 
• 6044-68-4 3,3-dimethoxyprop-1-ene 

Downstream Products

• 17059-51-7 6-methyl benzofuran 
• 35664-71-2 5-phenyl benzo[b]furan 
• 18441-43-5 5-methylbenzofuran 

Relevant articles and documents

Preparation method of 2, 2-dimethoxyacetaldehyde

The invention discloses a preparation method of 1, 2-dimethoxyacetaldehyde. Hydroxyacetaldehyde is adopted as a raw material and a methanol raw material, S2O8 /Zn-MCM-41 solid superacid is adopted as a catalyst, the acidity is high and 2, 2-methoxyethanol can be obtained with high selectivity, then 2, 2-methoxyacetaldehyde is obtained under the action of an oxidizing agent, the product is easy to separate, and the purity of dimethoxyacetaldehyde reaches up to 95% or above.

A atorvastatin sandbank calcium chiral synthesis of intermediates method

The invention discloses a synthesis method for a chiral intermediate of atorvastatin calcium, and belongs to the technical field of medical intermediate synthesis. The synthesis method is characterized in that according to the process route, not only are dangerous, highly toxic and expensive chemicals such as butyl lithium, editpotassium cyanide and periodic acid in chemical synthesis prevented from being used, but also an ee value of the chiral intermediate is effectively improved due to usage of a mixed chiral catalysts of titanium iso-propylate and S-xenol. According to the synthesis method, the raw materials are low in cost and easy to obtain, the route operation is easy, the repeatability is good, the yield is very high, and the synthesis method is suitable for industrial production.

Metal-free, mild, nonepimerizing, chemo- and enantio- or diastereoselective N-alkylation of amines by alcohols via oxidation/imine-iminium formation/reductive amination: A pragmatic synthesis of octahydropyrazinopyridoindoles and higher ring analogues

A mild step and atom-economical nonepimerizing chemo- and enantioselective N-alkylating procedure has been developed via oxidation/imine-iminium formation/reduction cascade using TEMPO-BAIB-HEH-Bronsted acid catalysis in DMPU as solvent and a stoichiometric amount of amine. The optimized conditions were further extended for the nonenzymatic kinetic resolution of the chiral amine thus formed under nonenzymatic in situ hydrogen-transfer conditions using VAPOL-derived phosphoric acid (VAPOL-PA) as the Bronsted acid catalyst. The enantioselective cascade of the presented reaction was successfully utilized in the synthesis of octahydropyrazinopyridoindole and its higher ring analogues.