methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate

Base Information

• Chemical Name: methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate
• CAS No.: 1581266-93-4
• Molecular Formula: C₄₀H₄₅NO₅S₂
• Molecular Weight: 683.933

Synonyms:methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate

Chemical Property of methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate

Chemical Property:

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Technology Process of methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate

There total 2 articles about methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoic acid (1027785-31-4) + methyl D-methioninate hydrochloride (69630-60-0) → methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate (1581266-93-4)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1055/s-0037-1612059

Reference yield: 99.0%

D-methionine methyl ester (21691-49-6,874219-77-9) + (S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoic acid (1027785-31-4) → methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate (1581266-93-4)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.02.044

Reference yield: 100.0%

methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate (1581266-93-4) → (R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamide]-4-(methylthio)butanoic acid (1581266-95-6)

Guidance literature:

With lithium hydroxide; In methanol; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2014.02.044

upstream raw materials:

D-methionine methyl ester

(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoic acid

methyl D-methioninate hydrochloride

Downstream raw materials:

(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamide]-4-(methylthio)butanoic acid

(3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]-4-(methylthio)butanoylamino]-3-tritylthio(propionylamino)}-5-methylhexanoate

(2S,6R,9S,12R,13S)-12-[(S)-isobutyl]-13-(tert-butyldimethylsilyloxy)-6-[2-(methylthio)ethyl]-2-[(E)-4-(tritylthio)but-1-en-1-yl]-9-tritylthiomethyl-1-oxa-5,8,11-triazacyclopentadecane-4,7,10,15-tetraone

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