69630-60-0

Basic information

• Product Name: H-D-MET-OME HCL
• Synonyms: (R)-Methyl 2-amino-4-(methylthio)butanoate hydrochloride;D-Methionine methyl ester hydrochloride≥ 98% (HPLC);D-METHIONINE METHYL ESTER HYDROCHLORIDE;D-METHIONINE METHYL ESTER HYDROCHLORIDE SALT;H-D-MET-OME HCL;D-methionine methyl ester hcl;H-D-Met-Ome;H-D-Met-OMe•
• CAS NO: 69630-60-0
• Molecular Formula: C₆H₁₃NO₂S*ClH
• Molecular Weight: 199.7
• Product Categories: Amino Acids;Methionine [Met, M];Amino Acids and Derivatives;Amino hydrochloride
• Mol File: 69630-60-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 149-150 °C
• Boiling Point: 240 °C at 760 mmHg
• Flash Point: 99 °C
• Appearance: /Solid
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: H-D-MET-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-MET-OME HCL(69630-60-0)
• EPA Substance Registry System: H-D-MET-OME HCL(69630-60-0)

Safety Data

• Hazardous Substances Data: 69630-60-0(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline

Uses

D-Methionine methyl ester is a protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).

Upstream product

• 348-67-4 D-methionine 
• 67-56-1 methanol 
• 21691-49-6 D-methionine methyl ester 
• 84228-57-9 D-methionine hydrochloride 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 127750-59-8 N-cinnamoyl-L-methionine methyl ester 
• 301162-05-0 (R)-N-[1-[(hydroxyamino)carbonyl]-3-(methylthio)propyl]-1-(4-methoxyphenyl)cyclopropanecarboxamide 
• 10420-68-5 N-(2,4-Dinitro-phenyl)-methionin-methylester 
• 40216-74-8 methyl-2-(benzylideneamino)-4-(methylthio)butyrate 
• 1581266-93-4 methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate 
• 40290-63-9 Methyl ester of N-t-butyloxycarbonyl-L-phenylalanyl-L-methionine 
• 80102-93-8 methyl Boc-2,6-dimethyl-DL-tyrosyl-D-methioninate 

Relevant articles and documents

Rhodium-Catalyzed Enantioselective Synthesis of Oxazinones via an Asymmetric Ring Opening-Lactonization Cascade of Oxabicyclic Alkenes

The rhodium-catalyzed asymmetric ring opening reaction of oxabicyclic alkenes is shown to be an efficient method for synthesizing chiral heterocycles. We demonstrate that the pairwise combination of chiral catalyst with chiral amino-acid-derived pronucleophiles results in a stereodivergent synthesis of diastereomeric hydroxyesters. A favorable conformational preference induces the subsequent lactonization of one diastereomer leading to the highly enantioselective synthesis of oxazinones.

NOVEL HDAC INHIBITORS AND METHODS OF TREATMENT USING THE SAME

Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.

DIPEPTIDES AS FEED ADDITIVES

The invention relates to feed additives containing dipeptides or salts thereof, in which one amino acid residue of the dipeptide is a DL-methionyl residue and the other amino acid residue of the dipeptide is an amino acid in the L-configuration selected from lysine, threonine, tryptophan, histidine, valine, leucine, isoleucine, phenylalanine, arginine, cysteine and cystine; feed mixtures containing these additives and method of producing the dipeptides.