(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester
CAS No.:1448718-97-5
Molecular Formula:C₂₈H₃₃Cl₂N₅O₄
Molecular Weight:574.507
Hs Code.:

Synonyms:(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

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Chemical Property of (S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

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Technology Process of (S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

There total 10 articles about (S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.1%

: 75-65-0
tert-butyl alcohol

: (S)-2-[[1-(2-azido-ethyl)-cyclopentane-carbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid

: 1448718-97-5
(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

Guidance literature:: (S)-2-[[1-(2-azido-ethyl)-cyclopentane-carbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid; With trifluoroacetic anhydride; In dichloromethane; for 2h; Cooling with ice; Inert atmosphere;

tert-butyl alcohol; In dichloromethane; at 20 ℃; Reflux;

Reference yield:

: 4630-80-2
methyl cyclopentane carboxylate

: 1448718-97-5
(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h / -70 - -50 °C

1.2: -70 - 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 15 h / 20 °C

5.1: trifluoroacetic anhydride / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

5.2: 20 °C / Reflux

With n-butyllithium; sodium azide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 103724-64-7
1-(2-bromoethyl)cyclopentane carboxylic acid methyl ester

: 1448718-97-5
(S)-2-[[1-(2-azido-ethyl)-cyclopentanecarbonyl]-amino]-3-[4-(2,6-dichloro-benzoylamino)-phenyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 5 h / 50 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 48 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; ethanol / 15 h / 20 °C

4.1: trifluoroacetic anhydride / dichloromethane / 2 h / Cooling with ice; Inert atmosphere

4.2: 20 °C / Reflux

With sodium azide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;