3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Base Information

Chemical Name:3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide
CAS No.:1283600-75-8
Molecular Formula:C₃₄H₃₄N₂O₈
Molecular Weight:598.653
Hs Code.:

Synonyms:3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

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Chemical Property of 3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

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Technology Process of 3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

There total 4 articles about 3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1283600-50-9
2'-formyl-4,4',5,6-tetramethoxybiphenyl-2-carboxylic acid

: 10349-38-9
p-methoxyphenylisonitrile

: 2393-23-9
4-methoxy-benzylamine

: 1283600-75-8
3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Guidance literature:: With sodium sulfate; In 2,2,2-trifluoroethanol; at 110 ℃; for 0.833333h; Sealed; Inert atmosphere; Irradiation;
DOI:10.1021/jo200251q

Reference yield:

: 1283600-47-4
methyl 2'-formyl-4,4',5,6-tetramethoxy-[1,1'-biphenyl]-2-carboxylate

: 1283600-75-8
3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

1.2: pH 7

2.1: sodium sulfate / 2,2,2-trifluoroethanol / 0.83 h / 110 °C / Sealed; Inert atmosphere; Irradiation

With water; sodium sulfate; lithium hydroxide; In tetrahydrofuran; 2,2,2-trifluoroethanol; 2.1: Ugi 4CR reaction;
DOI:10.1021/jo200251q

Reference yield:

: 1968-71-4
methyl 2-bromo-3,4,5-trimethoxybenzoate

: 1283600-75-8
3,9,10,11-tetramethoxy-6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.42 h / 120 °C / Sealed; Irradiation

2.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

2.2: pH 7

3.1: sodium sulfate / 2,2,2-trifluoroethanol / 0.83 h / 110 °C / Sealed; Inert atmosphere; Irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; sodium sulfate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; 2,2,2-trifluoroethanol; water; 1.1: Suzuki-Miyaura cross-coupling / 3.1: Ugi 4CR reaction;
DOI:10.1021/jo200251q