Chemical Property of Cetylpyridinium Chloride
Chemical Property:
- Appearance/Colour:white powder or crystals
- Vapor Pressure:0Pa at 25℃
- Melting Point:77 °C
- Refractive Index:1.6000 (estimate)
- Boiling Point:496.25°C (rough estimate)
- PSA：3.88000
- Density:0.9362 (rough estimate)
- LogP:3.45940
- Storage Temp.:Inert atmosphere,Room Temperature
- Solubility.:Freely soluble in water; very soluble in chloroform;
very slightly soluble in ether; insoluble in acetone, acetic acid,
and ethanol.
- Water Solubility.:111g/L at 20℃
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:15
- Exact Mass:339.2692779
- Heavy Atom Count:23
- Complexity:208
- Purity/Quality:
-
99%min *data from raw suppliers
Cetylpyridinium chloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Chemical Classes:Nitrogen Compounds -> Quaternary Amines
- Canonical SMILES:CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1.[Cl-]
- Recent ClinicalTrials:Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
- Recent EU Clinical Trials:A COMPARISON OF THERAPEUTIC EQUIVALENCE BETWEEN THE TEST AND THE REFERENCE FORMULATION OF FIXED COMBINATION OF CETYLPYRIDINIUM CHLORIDE 1.0 mg/BENZYDAMINE HYDROCHLORIDE 3 mg IN SUBJECTS WITH SORE THROAT ASSOCIATED WITH UPPER RESPIRATORY TRACT INFECTIONS
- Recent NIPH Clinical Trials:An exploratory research of the effects of comprehensive oral care, including antibiotics on the tongue, in patients who underwent resection and reconstruction of oral cancer
-
Description
Cetylpyridinium is a quaternary ammonium with broad-spectrum antiseptic activities. It is active against S. mutans, S. sanguis, E. coli, Oxford Staphylococcus, and C. albicans in media (MICs = 1.25-62.5 μg/ml) and against Oxford Staphylococcus in pooled human saliva (MICs = 7.8-15.6 μg/ml). Cetylpyridinium slows plaque formation for at least 21 days compared to a deionized water control in a rat incisor plaque model when applied topically at concentrations ranging from 0.025 to 2%. Formulations containing cetylpyridinium have been used as antiseptic agents in the treatment of gingivitis and as antimicrobial agents in raw food processing.
-
Uses
Antibacterial in cough lozenges and syrups;
emulsifier. quaternary ammonium compound used as a preservative in cosmetics and pharmaceuticals; topical anti-infective and
disinfectant; used on the surface of latex gloves .
-
Clinical Use
1-Hexadecylpyridinium chloride is a white powder that isvery soluble in water and alcohol. In Cetylpyridinium chloride, thequaternary nitrogen atom is a member of an aromatic pyridinering.The cetyl derivative is the most active of a series ofalkylpyridinium compounds. It is used as a general antisepticin concentrations of 1:100 to 1:1,000 for intact skin,1:1,000 for minor lacerations, and 1:2,000 to 1:10,000 forthe irrigation of mucous membranes. Cetylpyridinium chlorideis also available in the form of throat lozenges and amouthwash at a 1:20,000 dilution.
