Technology Process of 6-difluoromethyl-1,2-dihydro-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester
There total 10 articles about 6-difluoromethyl-1,2-dihydro-2-oxo-1-phenylpyridine-3-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 5 - 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Heating / reflux
2: triethylamine / acetonitrile / 2 h / 0 - 20 °C
3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Heating / reflux; Irradiation
4: water; sodium hydrogencarbonate / 1,4-dioxane / 3 h / 60 °C
5: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 8 h / 65 °C
6: Dess-Martin periodane / dichloromethane / 4 h / 20 °C
7: diethylamino-sulfur trifluoride / dichloromethane / 5 - 20 °C
With
N-Bromosuccinimide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); diethylamino-sulfur trifluoride; water; ammonium formate; sodium hydrogencarbonate; Dess-Martin periodane; triethylamine;
palladium 10% on activated carbon; N,N-dimethyl-formamide;
In
1,4-dioxane; tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 5 h / Heating / reflux; Irradiation
2: water; sodium hydrogencarbonate / 1,4-dioxane / 3 h / 60 °C
3: ammonium formate / palladium 10% on activated carbon / ethyl acetate / 8 h / 65 °C
4: Dess-Martin periodane / dichloromethane / 4 h / 20 °C
5: diethylamino-sulfur trifluoride / dichloromethane / 5 - 20 °C
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethylamino-sulfur trifluoride; water; ammonium formate; sodium hydrogencarbonate; Dess-Martin periodane;
palladium 10% on activated carbon;
In
1,4-dioxane; tetrachloromethane; dichloromethane; ethyl acetate;
