(E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate

Base Information

• Chemical Name: (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate
• CAS No.: 1430217-55-2
• Molecular Formula: C₃₂H₃₃ClN₈O₄
• Molecular Weight: 629.118
• Mol file: 1430217-55-2.mol

Synonyms:(E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate

Chemical Property of (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate

There total 7 articles about (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-tert-butyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate (1430217-54-1) → (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate (1430217-55-2)

Guidance literature:

(E)-tert-butyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate; With ammonium chloride; In ethanol; at 0 ℃; for 0.0833333h;

With indium; In ethanol; for 3h; Reflux;

Reference yield:

t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (570409-62-0) → (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate (1430217-55-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 0 °C

2.1: iodine; mercury(II) oxide / dichloromethane / 1 h / 0 °C

3.1: methanol / 24 h / Reflux

4.1: ammonium chloride / ethanol / 0.08 h / 0 °C

4.2: 3 h / Reflux

With hydrogenchloride; methanol; iodine; ammonium chloride; mercury(II) oxide; In 1,4-dioxane; ethanol; dichloromethane; 3.1: |Ugi Condensation;

Reference yield:

8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine (1430217-53-0) → (E)-tert-butyl 4-(3-amino-6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate (1430217-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 24 h / Reflux

2.1: ammonium chloride / ethanol / 0.08 h / 0 °C

2.2: 3 h / Reflux

With methanol; ammonium chloride; In ethanol; 1.1: |Ugi Condensation;

upstream raw materials:

8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine

t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine

(E)-tert-butyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)benzoate