2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Base Information

Chemical Name:2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
CAS No.:121138-48-5
Molecular Formula:C₂₅H₂₃F₃N₄O₇
Molecular Weight:548.475
Hs Code.:

Synonyms:2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

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Chemical Property of 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

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Technology Process of 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

There total 5 articles about 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

: 121138-48-5
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: With nitric acid; In ethyl acetate; at 60 ℃; for 2h;

Reference yield:

: bis(2-cyanoethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine 3,5-dicarboxylate

: 121138-48-5
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / 0.1 N NaOH / tetrahydrofuran / 0.67 h

2: SOCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

3: dimethylformamide; CH₂Cl₂ / 4 h

4: 77 percent / tetrahydrofuran / 4 h / Ambient temperature

5: 98 percent / 2 N HNO₃ / ethyl acetate / 2 h / 60 °C

With sodium hydroxide; thionyl chloride; nitric acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 5-Chlorocarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester

: 121138-48-5
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide; CH₂Cl₂ / 4 h

2: 77 percent / tetrahydrofuran / 4 h / Ambient temperature

3: 98 percent / 2 N HNO₃ / ethyl acetate / 2 h / 60 °C

With nitric acid; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;