2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

Base Information

Chemical Name:2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide
CAS No.:121138-49-6
Molecular Formula:C₂₅H₂₃F₃N₄O₈
Molecular Weight:564.475
Hs Code.:

Synonyms:2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

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Chemical Property of 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

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Technology Process of 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

There total 6 articles about 2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 121138-48-5
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

: 121138-49-6
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

Guidance literature:: With dihydrogen peroxide; In acetic acid; at 80 ℃; for 5.5h;

Reference yield:

: bis(2-cyanoethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine 3,5-dicarboxylate

: 121138-49-6
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 45 percent / 0.1 N NaOH / tetrahydrofuran / 0.67 h

2: SOCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

3: dimethylformamide; CH₂Cl₂ / 4 h

4: 77 percent / tetrahydrofuran / 4 h / Ambient temperature

5: 98 percent / 2 N HNO₃ / ethyl acetate / 2 h / 60 °C

6: 89 percent / 31 percent H₂O₂ / acetic acid / 5.5 h / 80 °C

With sodium hydroxide; thionyl chloride; dihydrogen peroxide; nitric acid; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 5-Chlorocarbonyl-2,6-dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 2-cyano-ethyl ester

: 121138-49-6
2-cyanoethyl N-trifluoroacetyl-3-piperidinyl-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate N-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylformamide; CH₂Cl₂ / 4 h

2: 77 percent / tetrahydrofuran / 4 h / Ambient temperature

3: 98 percent / 2 N HNO₃ / ethyl acetate / 2 h / 60 °C

4: 89 percent / 31 percent H₂O₂ / acetic acid / 5.5 h / 80 °C

With dihydrogen peroxide; nitric acid; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;