N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Base Information

Chemical Name:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate
CAS No.:365432-00-4
Molecular Formula:C₂₁H₂₇ClN₃O₉P
Molecular Weight:531.887
Hs Code.:

Synonyms:N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Suppliers and Price of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

There total 7 articles about N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 365431-88-5
(S)-2-Acetylamino-3-{4-[[(4-chloro-butyl)-methyl-amino]-(5-nitro-furan-2-ylmethoxy)-phosphoryloxy]-phenyl}-propionic acid allyl ester

: 365432-00-4
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm060142p

Reference yield:

: 365432-14-0
N-acetyl-L-tyrosine allyl ester

: 365432-00-4
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / -15 - -5 °C

2: LiHMDS / tetrahydrofuran / 5.5 h / -40 °C

3: 0.15 g / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm060142p

Reference yield:

: 365432-18-4
N-methyl-N-(4-chlorobutyl) O-(4-((S)-2-acetylamino-2-carboxyallylethyl))phenyl phosphoramidic chloride

: 365432-00-4
N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) O-(4-((S)-2-acetylamino-2-carboxyethyl))phenyl phosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1: LiHMDS / tetrahydrofuran / 5.5 h / -40 °C

2: 0.15 g / aq. sodium p-toluenesulfinate; Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium 4-methylbenzenesulfinate; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm060142p