2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

Base Information

Chemical Name:2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine
CAS No.:630104-48-2
Molecular Formula:C₃₁H₅₀N₂O₈Si₂
Molecular Weight:634.918
Hs Code.:

2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

Synonyms:2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

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Chemical Property of 2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

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Technology Process of 2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

There total 8 articles about 2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2746-25-0
p-Methoxybenzyl bromide

: 681277-20-3
(2S,3S,3aS,9aR)-2-(2,4-Dimethoxy-pyrimidin-5-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ol

: 630104-48-2
2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol030095k

Reference yield:

: 5336-08-3
D-Ribono-1,4-lactone

: 630104-48-2
2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 84 percent / pyridinium p-toluenesulfonate; anhydrous Na₂SO₄ / 1 h / 60 °C

2.1: t-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 65 percent / tetrahydrofuran; hexane / 1.5 h / -78 °C

3.1: NaBH₄ / methanol

4.1: 86 percent / Ph₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 0 °C

5.1: 84 percent / acetic acid / 2 h / Heating

6.1: 95 percent / pyridine / 4 h / 20 °C

7.1: 84 percent / NaH / dimethylformamide; tetrahydrofuran; toluene / 15 h

With pyridine; sodium tetrahydroborate; di-isopropyl azodicarboxylate; tert.-butyl lithium; pyridinium p-toluenesulfonate; sodium hydride; acetic acid; sodium sulfate; triphenylphosphine; In tetrahydrofuran; methanol; hexane; N,N-dimethyl-formamide; toluene; 4.1: Mitsunobu reaction;
DOI:10.1016/j.tet.2005.12.066

Reference yield:

: 630104-47-1
2,4-Dimethoxy-5-[(3aS,4S,6R,6aR)-6-(1-methoxy-1-methyl-ethoxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-pyrimidine

: 630104-48-2
2,4-Dimethoxy-5-[(2S,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(4-methoxy-benzyloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / acetic acid / 2 h / Heating

2: 95 percent / pyridine / 4 h / 20 °C

3: 84 percent / NaH / dimethylformamide; tetrahydrofuran; toluene / 15 h

With pyridine; sodium hydride; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2005.12.066