2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

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Chemical Name:2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide
CAS No.:1190393-38-4
Molecular Formula:C₂₅H₂₈N₄O₂S
Molecular Weight:448.589
Hs Code.:

Synonyms:2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

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Chemical Property of 2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

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Technology Process of 2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

There total 11 articles about 2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1287760-56-8
tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate

: 1190393-38-4
2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

Guidance literature:: tert-butyl (2S,5R)-2-(4[({2-[(tert-butoxycarbonyl)amino]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazol-4-yl}carbonyl)amino]benzyl)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

With ammonia; In methanol;

Reference yield:

: 1190391-90-2
tert-butyl (2R,5S)-2-[(R)-hydroxy(phenyl)methyl]-5-(4-nitrobenzyl)pyrrolidine-1-carboxylate

: 1190393-38-4
2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

3: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: tert-butyl (4S,5R)-4-formyl-2,2-dimethyl-5-phenyloxazolidine-3-carboxylate

: 1190393-38-4
2-amino-N-[4-{((2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyroolidin-2-yl)methyl}phenyl]-5,6-dihydro-4H-cyclopenta[α][1,3]thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 40 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / acetone / 24 h / 20 °C

3.1: triethylamine / dichloromethane / 48 h / 20 °C

4.1: hydrogenchloride; water / ethyl acetate / 5 h / 20 - 45 °C

4.2: 7 h / 20 °C

4.3: 20 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;